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. 1972 Dec;69(12):3673–3676. doi: 10.1073/pnas.69.12.3673

Partial Duplication in the “Hinge” Region of IgA1 Myeloma Proteins

Blas Frangione 1, Carlota Wolfenstein-Todel 1
PMCID: PMC389846  PMID: 4509329

Abstract

The aminoacid sequence of the “hinge” region of two human IgA1 myeloma proteins was found to be identical. A 30-residue fragment contains 3 cysteines, 12 prolines, and carbohydrate, and the sequence of a small segment of the hinge region is repeated at least twice. Since a deletion of 12-13 residues was found in the same region of an IgA2 myeloma protein, it is possible that IgA1 molecules are the result of the insertion of a partially duplicated gene segment in the immunoglobulin genes.

Keywords: aminoacid sequence, duplication, recombination, gene fusion, evolution

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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