Table 1.
Selected genes upregulated in Th1Th17 vs. Th1
| Gene symbol | Fold change Th1Th17/Th1 | p-value | Gene title |
|---|---|---|---|
| IL17A |
44,94 |
0,000 |
Interleukin 17A |
| IL22 |
29,18 |
0,000 |
Interleukin 22 |
| CCL20 |
26,69 |
0,000 |
Chemokine (C-C motif) ligand 20 |
| IL17F |
10,47 |
0,039 |
Interleukin 17 F |
| RORC |
7,73 |
0,000 |
RAR-related orphan receptor C |
| IL26 |
6,90 |
0,000 |
Interleukin 26 |
| IL23R |
6,14 |
0,000 |
Interleukin 23 receptor |
| CTSH |
5,46 |
0,000 |
Cathepsin H |
| CCR6 |
5,38 |
0,001 |
Chemokine (C-C motif) receptor 6 |
| HPGD |
5,16 |
0,004 |
Hydroxyprostaglandin dehydrogenase 15-(NAD) |
| PTPN13 |
4,45 |
0,000 |
Protein tyrosine phosphatase, non-receptor type 13 |
| KLRB1 |
3,87 |
0,040 |
Killer cell lectin-like receptor subfamily B, member 1 |
| IL1R1 |
3,39 |
0,004 |
Interleukin 1 receptor, type I |
| CSF2 |
2,68 |
0,041 |
Colony stimulating factor 2 (granulocyte-macrophage) |
| LST1 |
2,60 |
0,001 |
Leukocyte specific transcript 1 |
| CXCR6 |
2,44 |
0,003 |
Chemokine (C-X-C motif) receptor 6 |
| MCAM |
2,27 |
0,001 |
Melanoma cell adhesion molecule |
| CCR2 |
2,25 |
0,034 |
Chemokine (C-C motif) receptor 2 |
| RORA |
2,14 |
0,005 |
RAR-related orphan receptor A |
| CD80 |
2,08 |
0,013 |
CD80 molecule |
| IL18RAP |
2,05 |
0,049 |
Interleukin 18 receptor accessory protein |
| PPARG |
2,04 |
0,019 |
Peroxisome proliferator-activated receptor gamma |
| TNFRSF25 |
2,01 |
0,008 |
Tumor necrosis factor receptor superfamily, member 25 |
| TNFSF13B |
1,95 |
0,014 |
Tumor necrosis factor (ligand) superfamily, member 13b |
| LTB |
1,87 |
0,012 |
Lymphotoxin beta (TNF superfamily, member 3) |
| ARNTL |
1,72 |
0,024 |
Aryl hydrocarbon receptor nuclear translocator-like |
| IL15 |
1,69 |
0,012 |
Interleukin 15 |
| FURIN |
1,61 |
0,040 |
Furin (paired basic amino acid cleaving enzyme) |
| IL12RB1 |
1,56 |
0,031 |
Interleukin 12 receptor, beta 1 |
| ATF5 |
1,54 |
0,004 |
Activating transcription factor 5 |
| THY1 |
1,54 |
0,043 |
Thy-1 cell surface antigen |
| MAP3K4 |
1,53 |
0,003 |
Mitogen-activated protein kinase kinase kinase 4 |
| CEACAM1 |
1,52 |
0,021 |
Carcinoembryonic antigen-related cell adhesion molecule 1 |
| MAP3K4 |
1,52 |
0,006 |
Mitogen-activated protein kinase kinase kinase 4 |
| IL2 |
1,51 |
0,041 |
Interleukin 2 |
| ATF5 |
1,46 |
0,018 |
Activating transcription factor 5 |
| CTSC |
1,43 |
0,023 |
Cathepsin C |
| CD40LG |
1,45 |
0,037 |
CD40 ligand |
| RUNX1 |
1,40 |
0,012 |
Runt-related transcription factor 1 |
| PTEN |
1.39 |
0.031 |
Phosphatase and tensin homolog |
| CD28 |
1,37 |
0,046 |
CD28 molecule |
| TRIM8 |
1,36 |
0,011 |
Tripartite motif-containing 8 |
| CASP4 |
1,34 |
0,025 |
Caspase 4, apoptosis-related cysteine peptidase |
| CYP27B1 |
1,33 |
0,031 |
Cytochrome P450, family 27, subfamily B, polypeptide 1 |
| FASLG | 1,33 | 0,046 | Fas ligand (TNF superfamily, member 6) |
Shown are 44 differentially expressed genes (p-value <0.05 and cut-off 1.3 fold) that are preferentially expressed in Th1Th17 vs. Th1 cells.