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Published in final edited form as: Int J Math Math Sci. 2010 Feb 19;2010:915958. doi: 10.1155/2010/915958

Geometric Sensitivity of a Pinhole Collimator

Howard Jacobowitz 1, Scott D Metzler 2,*
PMCID: PMC3898866  NIHMSID: NIHMS511268  PMID: 24465067

Abstract

Geometric sensitivity for single photon emission computerized tomography (SPECT) is given by a double integral over the detection plane. It would be useful to be able to explicitly evaluate this quantity. This paper shows that the inner integral can be evaluated in the situation where there is no gamma ray penetration of the material surrounding the pinhole aperature. This is done by converting the integral to an integral in the complex plane and using Cauchy’s theorem to replace it by one which can be evaluated in terms of elliptic functions.

Keywords: SPECT, geometric sensitivity, computerized tomography, residue theorem, contour integration, elliptic functions

1 Introduction

Nuclear-medicine imaging provides images that assess how the body is functioning [1, 2], as opposed to anatomical modalities (e.g., x-ray computed tomograpy, commonly known as a CT or ‘CAT’ scans) that provide little or no information about function, but great detail of the body’s structure. Nuclear-medicine images the biodistribution of radiolabeled molecules that are typically intravenously injected into the patient in tracer (i.e., non-pharmacological) quantitites. The compounds may have different biochemical properties that affect the biodistribution and, hence, the choice of pharmaceuticals used to assess the disease state of a patient.

Two common nuclear-medicine techniques are single photon emission computed tomography (SPECT) and positron emission tomography (PET). Molecules labeled with a SPECT tracer emit a single photon. PET tracers emit a positron, which annihilates with a nearby electron to produce two nearly back-to-back photons at 511 keV, the rest energy of an electron. The line of these two photons contains the emission point of the positron. Many photon pairs are detected in coincidence and reconstructed into a three-dimensional (3D) image of the tracer’s distribution.

Since SPECT tracers emit only one photon, the detection of the photon itself gives little information about the location of the emission since neither the direction nor origin of the emission is known. Consequently, SPECT uses collimation that allows only photons along certain lines to be detected. The origin is still unknown, but the 3D image may be reconstructed when photons from numerous angles are detected [3, 4]. Pinhole collimation is often used when a small organ (e.g., the thyroid) is imaged by a large detector with a SPECT tracer. Figure 1 is a diagram of the apparatus. It is not hard to see that the pinhole collimation’s geometric efficiency, namely, the fraction of emitted photons that pass through the circular aperture of the collimator, is approximately given by:

g=d2sin3θ16h2, (1.1)

where d is the diameter of the pinhole, h is the perpendicular distance, and θ is the incidence angle of the photon on the aperture plane at the center of aperture. This formula becomes exact in the limit that d goes to zero. Also, an exact formula is easily obtained when θ=π2:

g(θ=π2)=1212[1+(d2h)2]121212[112(d2h)2]=d216h2. (1.2)

We derive stronger versions of these two results in the next section. But the main goal of this paper is to simplify the integral representation for the geometric sensitivity without taking d or θπ/2 to be small. We are concerned with the case where there is no penetration in the sense that not all gamma rays are stopped by the attenuating material surrounding the pinhole aperture. We take θπ/2. The geometric sensitivity, as defined above, is given by the integral over the aperture of the flux times the sine of the incidence angle at that point on the aperture:

g=14πh20d2ρdρ02πdβsin3θa, (1.3)

where ρ and β are polar coordinates on the aperture plane and θa is the incidence angle of the photon at a particular value of ρ and β, and is given by [6]:

cot2θa=cot2θ2ρhcotθcos(βϕ)+ρ2h2,

where ϕ is the third coordinate of the point source. For integrals over 2π the difference βϕ can be replaced with only β without loss of generality. This yields

sin2θa=[csc2θ2ρhcotθcosβ+ρ2h2]1.

Figure 1.

Figure 1

Perspective View of the Knife-edge Pinhole Collimator. A point source at z = h and angle θ emits a photon that intersects the z = 0 plane at (ρ cos β, ρ sin β, 0) with an incident angle θa. The acceptance angle of the collimator is α and the diameter of the aperture is d. ΔL is the path length of the photon in the attenuating medium. Reproduced from [6] with permission (© 2001 IEEE).

Applying this to (1.3),

g=14πh20d2ρdρ02πdβ[csc2θ2ρhcotθcosβ+ρ2h2]32, (1.4)

When there is penetration the above would be modified to

g=14πh20ρdρ02πdβ[csc2θ2ρhcotθcosβ+ρ2h2]32eμΔL, (1.5)

where the path length through attenuating material, ΔL, is zero for ρ<d2 and is otherwise given by (11) in Ref. [6].

Thus, (1.5) can be re-written as

g=gNP+14πh2d2ρdρ02πdβ[csc2θ2ρhcotθcosβ+ρ2h2]32eμΔL,=gNP+gPEN,

where gPEN is the efficiency due to penetration and gNP, the efficiency under the assumption of no penetration, is given by (1.4).

In this paper we use complex variable methods to calculate the β integral in (1.4).

2 Two approximations for gNP

The special form of gNP makes it easy to derive approximations for d/h small and for θπ/2 small which generalize equations (1.1) and (1.2). Before doing this, we observe that only even powers of d and of θπ/2 can occur in the expansion of gNP. We see this by writing the integral as the sum of integrals from 0 to π and from π to 2π.

2.1 The expansion for d small

Let us, in this section, denote gNP by g. Upon substituting r=d2h and η=ρh into (1.4) we obtain

g(r,θ)=14π02π0r[csc2θ2ηcotθcosβ+η2]32ηdηdβ.=14π02π(0rηϕ(β,η,θ)dη)dβ.

Clearly, g(0, θ) = 0. Since

gr(r,θ)=14π02πrϕ(β,r,θ)dβ

we have gr(0, θ) = 0. Differentiating (2.1) three more times with respect to r we obtain

grr(r,θ)=14π02π(rϕr(β,0,θ)+ϕ(β,r,θ))dβgrrr(r,θ)=14π02π(rϕrr(β,0,θ)+2ϕr(β,r,θ))dβgrrrr(r,θ)=14π02π(rϕrrr(β,0,θ)+3ϕrr(β,r,θ))dβ

and then setting r = 0 in each of the resulting equations we obtain

grr(0,θ)=14π02πϕ(β,0,θ)dβgrrr(0,θ)=12π02πϕr(β,0,θ)dβgrrrr(0,θ)=34π02πϕrr(β,0,θ)dβ.

For convenience let us write

u=csc2θandv=cotθ

so ϕ becomes

ϕ(β,r,θ)=(u2vrcosβ+r2)32.

Then

ϕ(β,0,θ)=u32ϕr(β,0,θ)=3u52vcosβϕrr(β,0,θ)=15u72v2cos2β3u52.

We substitute into the Taylor expansion

g(r,θ)=g(0,θ)+gr(0,θ)r+12!grr(0,θ)r2+13!grrr(0,θ)r3+14!grrrr(0,θ)r4+

and obtain

g(r,θ)=12(14π02πu32dβ)r2+13!(32π02π6u52vcosβdβ)r3+14!(14π02π3(15u72v2cos2β3u52)dβ)r4+.

Since

02πcosβdβ=0and02πcos2βdβ=π

and u−1 = sin2 θ we obtain

g(r,θ)=r24sin3θ+332(5sin5θcos2θ2sin5θ)r4+.

Finally we replace cos2 θ by 1 − sin2 θ and r by d/2h and obtain.

gNP=116sin3θ(dh)2+3512sin5θ(35sin2θ)(dh)4+O(d6), (2.1)

2.2 The expansion for θπ2 small

To start we let

f(θ,η,β)=(csc2θ2ηcotθcosβ+η2)32

and compute its Taylor expansion at θ=π2,

f(θ,η,β)=(1+η2)323(1+η2)52ηcosβ(0π2)+12!(15(1+η2)72η2cos2β3(1+η2)52)(θπ2)2+O(θπ2)3.

Since

gNP=14π02π0d2hf(θ,η,β)ηdηdβ

and since we know that only even powers of θπ/2 occur, we obtain

gNP=12(111+(d2h)2)38(d2h)2(1+(d2h)2)52(θπ2)2+O(θπ2)4.

3 The Contour Integral

We have

I=02πdβ[csc2θ2ρhcotθcosβ+ρ2h2]32 (3.1)

and

gNP=14πh20d2Iρdρ.

I may be re-cast as a contour integral by setting z = e:

I=Γdziz[b2z(z22abz+1)]32=(2b)321iΓ[(zx0)(x1z)z]32dzz

where

Γis the unit circlea=csc2θ+ρ2h2b=2ρhcotθx0=ab[11b2a2]x1=ab[1+1b2a2].

We note that a > b and so 0 < x0 < 1 < x1.

In this section we take ρ, θ, and h to be constant. We write

F(z)=[z(zx0)(x1z)][z((zx0)(x1z))]12[1z]=1(zx0)(x1z)[z(zx0)(x1z)]12

and

I=(2b)321iΓF(z)dz.

We need to be careful because of the square roots. We use the usual convention that

limy0±1+iy=±i.

We wish to show that F(z) is holomorphic (and single-valued) in

{z:z<1}{x:0<x<x0}.

To isolate the square root factor in F we set

g(z)=z(zx0)(x1z).

We take ∣z∣ ≤ 1. If in addition Re z < 0 and ∣Im z∣ << ∣zx0∣ then Re (zx0)(x1z) < 0. This implies that g(z) never takes on negative real values and so has a single-valued square root in Re z < 0. Similarly, if ∣z∣ ≤ 1, and Re z > x0 (no condition on Im z now) then Re (zx0)(x1z) > 0 and g(z) has a single-valued square root Re z > x0.

It follows from Cauchy’s Theorem that the integral of F(z) over the unit circle Γ is equal to the integral over the “ barbell” γ around 0 and x0. More explicitly, γ is the boundary of

B=B(0)B(x0)R

where B(x) is the ball of radius and centered at x and R is the rectangle

R={z=x+iy:0xx0,δyδ}

with δ << . See Figure 2.

Figure 2.

Figure 2

The curve γ

The curve γ decomposes into smooth pieces which we describe using the angle α = arcsin(δ/∊).

γr={z:zx0=,π+αargzx0πα}γl={z:z=,αarg(z)2πα}γ±={z:z=x±iδ,cosαxx0cosα}.

To bound the integral over γ1 we set z = ∊e.

γlF(z)dz=α2παF(eiθ)eiθdθ=O(32).

To evaluate γr F(z)dz we set z = x0 + ∊e. Then

F(x0+eiθ)=C32e32iθ+O(12)

with

C=x012(x1x0)32 (3.2)

and so

γrF(z)dz=π+απα(32Ce32iθ+O(12))ieiθ(1+O())dθ=π+απαCi12iθ+O(12)dθ.

Since α = O(), we may set α = 0 and absorb the error in the O(1/2) term. We then do the integration and obtain

γrF(z)dz=4iC+O(12). (3.3)

We want to compute the integral of F over γ+. We need to be careful about the square root. Recall that we are assuming

cosα<x<x0cosαandδ<<.

Lemma 3.1

On γ+

F(z)=i((x0x)(x1x))32x12+O(δ)

and on γ

F(z)=i((x0x)(x1x))32x12+O(δ).

Proof

This is a consequence of the branching of the square root function. Let

H(z)=z(zx0)(x1z)=z(z¯x0)(x1z¯)zx02x1z2

and

h(z)=z(z¯x0)(x1z¯).

We see that

h(x+iδ)=x(xx0)(x1x)+iδ(x21)+O(δ2).

Recall that δ is replaced by −δ on γ and that 0 < x < x0 < x1. So Re H(z) < 0 on both γ+ and γ while Im H(z) < 0 on γ+ and Im H(z) > 0 on γ. Thus on γ+

H(z)12=ix(xx0)(x1x)12+O(δ)=i(x(x0x)(x1x)))12+O(δ)

while on γ

H(z)12=i(x(x0x)(x1x))12+O(δ)

Since

F(z)=F(x)+O(δ)=1(xx0)(x1x)H(z)12+O(δ)=1(x0x)(x1x)H(z)12+O(δ)=1(x0x)(x1x)(i(x(x0x)(x1x)))12+)O(δ))

the Lemma follows.

We also need to be careful about the orientation. The curve γ is oriented counter-clockwise. This means that the integration over γ+ goes in the direction of x0 to 0. We need to reverse its sign in order to write it in the conventional way.

γ+F(z)dz=cosαx0cosαF(x+iδ)dx=cosαx0cosαix12dx(x0x)32(x1x)32+O().

We let x = x0t and Δ=x01cosα and use δ << to obtain

γ+F(z)dz=Δ1Δix032t12dx(x0x0t)2(x1x0t)32+O().

Now let

τ=x1x0>1.

We have

γ+F(z)dz=ix032Δ1Δt12dt(τt)32(1t)32+O().

We may let Δ → 0 in the lower limit, but not in the upper limit. So we now have

γ+F(z)dz=ix03201Δt12dt(τt)32(1t)32+O(). (3.4)

Here Δ = ∊x0−1 cos α. We may let δ → 0 and redefine Δ to be ∊x0−1.

We get the same value for the integral over γ. This is because the integrand is the negative of that in (3.4) but the orientation is reversed and so the two negatives cancel.

For any function g(t), continuously differentiable on the interval [0, 1], we have

01Δg(t)(1t)32dt=2g(1)Δ122g(0)201(1t)12g(t)dt+O(Δ12).

as can easilly be seen by an integration by parts.

We apply this to g(t) = t1/2/(Γt)3/2 as in (3.4). This yields

γ+F(z)dz=2i(τ1)32x032Δ12+ix032(01t12(τ1)32+3t12(τ1)52dt)+O(12).

We now take twice this quantity and add to it the results of (3.2) and (3.3),

z=1F(z)dt=γF(z)dz=4iC+2(2ix0(x1x0)32)+(ix03201(1t)12((τt)32t12+3t12(τt)52)dt)+O(12).

We substitute the value for C from (3.2) and let → 0

z=1F(z)dz=2ix03202(1t)12((τt)32t12+3t12(τt)52)dt.

Finally, we evaluate this integral using Mathematica® and obtain

z=1F(z)dz=(2ix032)2(2τE[1τ](1+τ)K[1τ]))(τ1)2τ

where K and E are the complete elliptic functions of the first and second kind

K[m]=01(1mt2)12(1t2)12dtE[m]=01(1mt2)12(1t2)12dt.

We now have

I=(2b)321iΓF(z)dz=(2b)322x0322(2τE(1τ)(τ1)K(1τ))(τ1)2τ=(2b)324τ14(τ1)2(2τE(1τ)(τ1)K(1τ)) (3.5)

and

gNP=14πh20d2ρIdρ (3.6)

with

b=2ρhcotθ,a=cos2θ+ρ2h2 (3.7)
τ=x1x0=1x02x0=ab[11b2a2]x1=ab[1+1b2a2]. (3.8)

4 Limiting cases

We validate (3.5) by consider two limiting cases.

4.1 Expansion for Small d

We look for an expansion of gNP under the assumption that dh is small and rederive (2.1) The dependence of x0 on ρ is given in (3.8). The two-term Taylor expansion of x0 as a function of ρ is

x0=Aρ+Bρ3+O(ρ5) (4.1)

with

A=cosθsinθhandB=A3Ah2csc2θ. (4.2)

Since

τ=1x02

we have

1τ=A2ρ2+O(ρ4) (4.3)

and

1(τ1)2=1τ2+2τ3+O(ρ8). (4.4)

It is convenient to work with the quantity ρ2Γ, so we note, using (4.1)

ρ2τ=1A22BA3ρ2+O(ρ4). (4.5)

We start with

I=(2b)324τ14(τ1)2(2τE(1τ)(τ1)K(1τ)). (4.6)

Substituting the expression for b from (3.7) and for (Γ − 1)2 from (4.4) we obtain, after some manipulation

I=((hcotθ)324(ρ2τ)341τ+O(ρ4))(2τE(1τ)(τ1)K(1τ)).

We now use the expansions (as given by Mathematica®)

E(t)=π2πt8+O(t2)K(t)=π2+πt8+O(t2).

So

I=(hcotθ)324(ρ2τ)34(π2+π8τ+πτ)+O(ρ4).

From the expression for ρ2Γ in (4.5), we derive

1(ρ2τ)34=A32(1+32BAρ2+O(ρ4))

and this leads to

I=4(hcotθ)32A32(π2+π8τ+πτ+3Bρ2π4A)+O(ρ4).

We now substitute for A and B using (4.2) and also for Γ−1 using (4.3)

I=sin3θ(2π+3π2(3sin2θ5sin4θ)ρ2h2)+O(ρ4).

Substituting this into (3.6) and integrating, we again derive (2.1).

4.2 An expansion for θ near π/2

We show how (4.6) also gives the expansion of Section 2.2. We start with

x0=b2a(1+b24a2+O((ba)3)).

From (3.7) we see that

a=1+ρ2h2+(θπ2)2+O(θπ2)4 (4.7)
b=2ρh(θπ2)+O(θπ2)3. (4.8)

So from (3.8) we have

x0=b2a(1+b24a2+O(θπ2)3).

Thus

τ=4a2b22+O(θπ2)21(τ1)2=1τ2(1+2τ+O(θπ2)4) (4.9)

and

1τ(2τE(1τ)(τ1)K(1τ))=π2+9π8τ+O(θπ2)4.

These expansions let us write (4.6) as

I=(2b)324τ34((1+2τ)(π2+9π8τ+O(θπ2)4)=272(b2τ)34((1+2τ)(π2+9π8τ)+O(θπ2)4).

Using (4.8) and (4.9) we obtain a substitute for (4.1)

1(b2τ)34=434a32(1+3b28a2)+O(θπ2)4.

This gives, in light of (4.7),

I=2πa32+158πb2a72+O(θπ2)4=2π(1+ρ2h2)323π(1+ρ2h2)52(θπ2)2+152πρ2h2(1+ρ2h2)72(θπ2)2+O(θπ2)4.

Finally, we integrate term-by-term.

g=14πh20d2ρI(ρ)dρ=14πh2(2πh2(1(1+(d2h)2)12))3πh213(1(1+(d2h)2)32)(θπ2)2+(152πh2(2152+5(d2h)215(1+(d2h)2)52(θπ2)2)+O(θπ2)4=12(1(1+(d2h)2)12)38(1+(d2h)2)52(d2h)2(θπ2)2+O(θπ2)4.

5 Numerical Confirmation

The result of (3.5) is further validated in this section with numerical integration of (3.1). In this original formulation, the integral depends on the ratio of ρ/h and on the value of θ. We analytically considered one limiting case for each of these quantities in the previous section. We consider these and other values for these quantities in this section using numerical methods. For fixed values of ρ/h, the numerical integration (solid lines) is shown with the results of the residue calculation (open circles) in Fig. 3 as a function of θ. Fig. 4 shows the numerical integration and residue results for fixed values of θ as a function of ρ/h. All corresponding values of the residue calculation and the numerical integration agree.

Figure 3.

Figure 3

Numerical integration of (3.1) (solid lines) and residue calculation of (3.5) (open circles) as a function of θ for fixed values of ρ/h: 0.0, 0.2, 0.4, 0.6, 0.8, and 1.0.

Figure 4.

Figure 4

Numerical integration of (3.1) (solid lines) and residue calculation of (3.5) (open circles) as a function of ρ/h for fixed values of θ: 50, 60, 70, 80, and 90 degrees.

6 Conclusions

The accuracy of collimator efficiency is important for design and for quantitative reconstruction programs. Analytic forms obviate the need for numerical models, which do not readily offer insight into the interplay of collimator parameters. This paper approaches the problem by re-casting one of the integrals in terms of contour integration. This integration was completed, but the authors were unable to execute the second integral to yield a complete analytic solution. The result was studied for special cases with known outcomes for validation. Future efforts may be able to build on this validated result to find a complete analytic solution.

Contributor Information

Howard Jacobowitz, Department of Mathematical Sciences Rutgers University Camden, New Jersey 08102, USA jacobowi@camden.rutgers.edu.

Scott D. Metzler, Department of Radiology University of Pennsylvania Philadelphia, PA 19104 metzler@mail.med.upenn.edu.

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