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. Author manuscript; available in PMC: 2014 Apr 17.
Published in final edited form as: Oncogene. 2012 Nov 26;32(42):5089–5100. doi: 10.1038/onc.2012.525

Figure 7. Binary switch model for EWS/FLI mediated transcriptional regulation.

Figure 7

At directly repressed genes, such as LOX and TGFBR2, EWS/FLI may preferentially recruit transcriptional repressor complexes, such as the NuRD complex with its associated HDACs and LSD1, to transcriptionally inhibit gene expression. At other repressed loci, other repressor complexes could be recruited. In contrast, at directly activated genes, such as NR0B1 and GSTM4, EWS/FLI may preferentially recruit (yet to be determined) activator complexes to transcriptionally upregulate gene expression. The mechanism by which preferential recruitment occurs is not yet known.