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. 1983 Dec;80(23):7289–7292. doi: 10.1073/pnas.80.23.7289

Amplified C lambda and c-abl genes are on the same marker chromosome in K562 leukemia cells.

J R Selden, B S Emanuel, E Wang, L Cannizzaro, A Palumbo, J Erikson, P C Nowell, G Rovera, C M Croce
PMCID: PMC390040  PMID: 6580644

Abstract

The human leukemia cell line K562, derived from a patient with Philadelphia chromosome-positive chronic myelogenous leukemia, contains amplified c-abl oncogenes and unrearranged C lambda genes. Using in situ hybridization techniques, we have determined that the amplified c-abl and C lambda DNA sequences of K562 cells are both located on the same abnormal acrocentric marker chromosome, which may represent an altered Philadelphia chromosome.

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