Table 2.
Tissue | MiR-206 significance | Ref |
---|---|---|
Scleroderma | MiR-206 along with miR-21 may serve as a potential diagnostic tool for scleroderma. | 127 |
Pain control | MiR-206 inhibits the expression of substance P from its mRNA in human mesenchymal-stem-cells-derived neuronal cells. | 128 |
MiR-206 levels are changed in dorsal root ganglion and spinal cord dorsal horn in CFA-induced inflammatory response or during sciatic nerve ligation. | 129 | |
Biorhythms | MiR-206 is a part of the MyoD-miR-206-CLOCK-MyoD regulatory loop and thus participates in circadian rhythms regulation. | 130 |
Brown adipose tissue | MiR-206 expression is abundant in brown adipocytes and is missing in white adipocytes. This supports the idea that brown adipocytes and myocytes originate from a common cell lineage. | 131 |
Liver steatosis | MiR-206 suppresses liver X receptor α (LXRα) levels, thus inhibiting lipogenesis and serving as a potential therapeutic tool for future treatment of lipogenesis-associated diseases such as liver steatosis. | 132 |