Figure 5.

Protein expression profile across sixteen human organ types. Antibodies against ALT, AST, Glud1, and nineteen proteins which appeared to be liver-specific at the mRNA level were used in immunoblotting lysates of a human organ array. ALT, AST and GLUD1 were expressed in multiple organs. Five proteins (ALDOB, ASGR1, ASGR2, ASL and HMGCS2) were expressed in multiple organs which were not consistent with their mRNA expression profile. AGXT and COMT were expressed mainly in liver and heart. DPYS was expressed mainly in liver and kidney. Eight proteins (ALDH1L1, BHMT, CPS1, FAH, FBP1, GNMT, HPD, and MAT1A) were highly liver-specific. The arrow indicates the liver lysate lane.