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. 1996 Jun 25;93(13):6382–6386. doi: 10.1073/pnas.93.13.6382

Positive genetic feedback governs cAMP spiral wave formation in Dictyostelium.

H Levine 1, I Aranson 1, L Tsimring 1, T V Truong 1
PMCID: PMC39031  PMID: 8692824

Abstract

The aggregation stage of the life cycle of Dictyostelium discoideum is governed by the chemotactic response of individual amoebae to excitable waves of cAMP. We modeled this process through a recently introduced hybrid automata-continuum scheme and used computer simulation to unravel the role of specific components of this complex developmental process. Our results indicated an essential role for positive feedback between the cAMP signaling and the expression of the genes encoding the signal transduction and response machinery.

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Selected References

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