Table 2.
Of the 93 Significant GS-eQTL Association (p<10−10), mRNA Expression for Genes Within 36 GSs Were Associated with CDDP IC50 (p<10−4)
| Gene Set | N Genes | mRNA-IC50 GS p value | GS-eQTL p value |
|---|---|---|---|
| RNA binding | 715 | 8.0E-06 | 8.7E-10 |
| Cytoskeletal part | 870 | 1.2E-05 | 4.2E-17 |
| Intracellular non-membrane-bounded organelle | 2461 | 1.2E-05 | 1.1E-16 |
| Chromosome organization | 494 | 1.4E-05 | 3.4E-11 |
| Reg of cellular component organization | 454 | 1.6E-05 | 5.8E-11 |
| Neg reg of nitrogen compound metabolic process | 512 | 1.6E-05 | 4.8E-10 |
| Intracellular organelle lumen | 1779 | 2.8E-05 | 2.0E-13 |
| Organelle lumen | 1820 | 2.8E-05 | 4.9E-13 |
| Ribonucleoprotein complex | 490 | 2.8E-05 | 2.0E-11 |
| Neg reg of metabolic process | 770 | 3.0E-05 | 1.2E-10 |
| Neg reg of macromolecule metabolic process | 722 | 3.0E-05 | 2.1E-10 |
| Nuclear part | 1840 | 3.2E-05 | 4.8E-16 |
| Intracellular organelle part | 4711 | 4.2E-05 | 6.9E-25 |
| Reg of cell death | 824 | 5.2E-05 | 2.8E-12 |
| Cellular response to stress | 623 | 5.4E-05 | 8.6E-12 |
| Neg reg of cellular metabolic process | 710 | 5.4E-05 | 6.1E-11 |
| Transferase activity- transferring phosphorus-containing groups | 881 | 5.6E-05 | 3.4E-11 |
| Enzyme binding | 515 | 6.6E-05 | 2.1E-14 |
| Programmed cell death | 1080 | 6.6E-05 | 1.4E-13 |
| Protein complex assembly | 540 | 6.6E-05 | 4.4E-11 |
| Neg reg of biological process | 1797 | 6.8E-05 | 2.5E-15 |
| Purine nucleoside binding | 1566 | 6.8E-05 | 2.5E-14 |
| Gene expression | 3566 | 7.0E-05 | 2.1E-22 |
| Nucleobase- side- tide and nucleic acid metabolic process | 3911 | 7.0E-05 | 4.0E-22 |
| Intracellular organelle | 8658 | 7.2E-05 | 6.6E-28 |
| Cellular macromolecule metabolic process | 5664 | 7.2E-05 | 1.8E-23 |
| Pos reg of cellular process | 1795 | 7.4E-05 | 4.4E-13 |
| Hydrolase activity- acting on acid anhydrides | 753 | 7.6E-05 | 3.6E-12 |
| Intracellular membrane-bounded organelle | 7788 | 7.8E-05 | 1.3E-25 |
| Purine nucleotide binding | 1853 | 7.8E-05 | 7.2E-17 |
| Ribonucleotide binding | 1772 | 8.0E-05 | 1.5E-17 |
| Macromolecule biosynthetic process | 3384 | 8.2E-05 | 3.2E-22 |
| Intracellular part | 10298 | 8.6E-05 | 2.5E-29 |
| Neg reg of cellular process | 1641 | 8.6E-05 | 1.5E-13 |
| Intracellular | 10634 | 9.0E-05 | 1.0E-29 |
| Pos reg of cell death | 428 | 9.4E-05 | 2.6E-12 |
All GS-eQTL involved the genetic variation within the “Detection of abiotic stimulus” GS.