Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1983 Nov;80(21):6518–6522. doi: 10.1073/pnas.80.21.6518

Suppression of liver uptake of liposomes by dextran sulfate 500.

K R Patel, M P Li, J D Baldeschwieler
PMCID: PMC390384  PMID: 6195658

Abstract

The effect of dextran sulfate (DS, 500,000 Mr) and multilamellar vesicles (MLV) as liver blockade agents has been investigated in mice. Intravenous injection of unlabeled MLV prior to radioactive MLV caused moderate reduction in the liver uptake and increased tibia, lung, and spleen uptake. More drastic differences were observed with intraperitoneal injection of DS. When tested in the range of 0-50 mg of DS per kg of body weight, maximal liver blockade occurred at a dose of 50 mg. By using 50 mg of DS per kg, maximal liver blockade occurred at 12 hr after DS injection. The liver blockade was temporary, ending within 48 hr. The intraperitoneal route of injection for DS was more effective for liver blockade than the intravenous route.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abra R. M., Bosworth M. E., Hunt C. A. Liposome disposition in vivo: effects of pre-dosing with lipsomes. Res Commun Chem Pathol Pharmacol. 1980 Aug;29(2):349–360. [PubMed] [Google Scholar]
  2. Bangham A. D., Standish M. M., Watkins J. C. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol. 1965 Aug;13(1):238–252. doi: 10.1016/s0022-2836(65)80093-6. [DOI] [PubMed] [Google Scholar]
  3. Bonventre P. F., Gregoriandis G. Killing of intraphagocytic Staphylococcus aureus by dihydrostreptomycin entrapped within liposomes. Antimicrob Agents Chemother. 1978 Jun;13(6):1049–1051. doi: 10.1128/aac.13.6.1049. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Deshmukh D. S., Bear W. D., Brockerhoff H. Can intact liposomes be absorbed in the gut? Life Sci. 1981 Jan 19;28(3):239–242. doi: 10.1016/0024-3205(81)90728-1. [DOI] [PubMed] [Google Scholar]
  5. Ellens H., Mayhew E., Rustum Y. M. Reversible depression of the reticuloendothelial system by liposomes. Biochim Biophys Acta. 1982 Feb 25;714(3):479–485. doi: 10.1016/0304-4165(82)90157-x. [DOI] [PubMed] [Google Scholar]
  6. Fidler I. J., Barnes Z., Fogler W. E., Kirsh R., Bugelski P., Poste G. Involvement of macrophages in the eradication of established metastases following intravenous injection of liposomes containing macrophage activators. Cancer Res. 1982 Feb;42(2):496–501. [PubMed] [Google Scholar]
  7. Finkelstein M., Weissmann G. The introduction of enzymes into cells by means of liposomes. J Lipid Res. 1978 Mar;19(3):289–303. [PubMed] [Google Scholar]
  8. Ghosh P., Das P. K., Bachhawat B. K. Targeting of liposomes towards different cell types of rat liver through the involvement of liposomal surface glycosides. Arch Biochem Biophys. 1982 Jan;213(1):266–270. doi: 10.1016/0003-9861(82)90461-1. [DOI] [PubMed] [Google Scholar]
  9. Gregoriadis G. Drug entrapment in liposomes. FEBS Lett. 1973 Nov 1;36(3):292–296. doi: 10.1016/0014-5793(73)80394-1. [DOI] [PubMed] [Google Scholar]
  10. Gregoriadis G., Neerunjun E. D. Treatment of tumour bearing mice with liponsome-entrapped actinomycin D prolongs their survival. Res Commun Chem Pathol Pharmacol. 1975 Feb;10(2):351–362. [PubMed] [Google Scholar]
  11. Guilmette R. A., Cerny E. A., Rahman Y. E. Pharmacokinetics of the iron chelator desperrioxamine as affected by liposome encapsulation: potential in treatment of chronic hemosiderosis. Life Sci. 1978 Jan;22(4):313–320. doi: 10.1016/0024-3205(78)90138-8. [DOI] [PubMed] [Google Scholar]
  12. Hahn H. Effects of Dextran Sulfate 500 on Cell-Mediated Resistance to Infection with Listeria monocytogenes in Mice. Infect Immun. 1974 Nov;10(5):1105–1109. doi: 10.1128/iai.10.5.1105-1109.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Jonah M. M., Cerny E. A., Rahman Y. E. Tissue distribution of EDTA encapsulated within liposomes containing glycolipids or brain phospholipids. Biochim Biophys Acta. 1978 Jul 3;541(3):321–333. doi: 10.1016/0304-4165(78)90192-7. [DOI] [PubMed] [Google Scholar]
  14. Kao Y. J., Juliano R. L. Interactions of liposomes with the reticuloendothelial system. Effects of reticuloendothelial blockade on the clearance of large unilamellar vesicles. Biochim Biophys Acta. 1981 Nov 5;677(3-4):453–461. doi: 10.1016/0304-4165(81)90259-2. [DOI] [PubMed] [Google Scholar]
  15. Kataoka T., Kobayashi T. Enhancement of chemotherapeutic effect by entrapping 1-beta-D-arabinofuranosylcytosine in lipid vesicles and its mode of action. Ann N Y Acad Sci. 1978;308:387–394. doi: 10.1111/j.1749-6632.1978.tb22036.x. [DOI] [PubMed] [Google Scholar]
  16. Kosloski M. J., Rosen F., Milholland R. J., Papahadjopoulos D. Effect of lipid vesicle (liposome) encapsulation of methotrexate on its chemotherapeutic efficacy in solid rodent tumors. Cancer Res. 1978 Sep;38(9):2848–2853. [PubMed] [Google Scholar]
  17. Mauk M. R., Gamble R. C., Baldeschwieler J. D. Targeting of lipid vesicles: specificity of carbohydrate receptor analogues for leukocytes in mice. Proc Natl Acad Sci U S A. 1980 Aug;77(8):4430–4434. doi: 10.1073/pnas.77.8.4430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Mayhew E., Papahadjopoulos D., Rustum Y. M., Dave C. Use of liposomes for the enhancement of the cytotoxic effects of cytosine arabinoside. Ann N Y Acad Sci. 1978;308:371–386. doi: 10.1111/j.1749-6632.1978.tb22035.x. [DOI] [PubMed] [Google Scholar]
  19. Neerunjun E. D., Hunt R., Gregoriadis G. Fate of a liposome-associated agent injected into normal and tumour-bearing rodents: attempts to improve localization in tumour tissues [proceedings]. Biochem Soc Trans. 1977;5(5):1380–1383. doi: 10.1042/bst0051380. [DOI] [PubMed] [Google Scholar]
  20. Paphadjopoulos D., Wilson T., Taber R. Liposomes as vehicles for cellular incorporation of biologically active macromolecules. In Vitro. 1980 Jan;16(1):49–54. doi: 10.1007/BF02618199. [DOI] [PubMed] [Google Scholar]
  21. Patel K. R., Jonah M. M., Rahman Y. E. In vitro uptake and therapeutic application of liposome-encapsulated methotrexate in mouse hepatoma 129. Eur J Cancer Clin Oncol. 1982 Sep;18(9):833–843. doi: 10.1016/0277-5379(82)90193-6. [DOI] [PubMed] [Google Scholar]
  22. Proffitt R. T., Williams L. E., Presant C. A., Tin G. W., Uliana J. A., Gamble R. C., Baldeschwieler J. D. Liposomal blockade of the reticuloendothelial system: improved tumor imaging with small unilamellar vesicles. Science. 1983 Apr 29;220(4596):502–505. doi: 10.1126/science.6836294. [DOI] [PubMed] [Google Scholar]
  23. Rahman Y. E., Cerny E. A., Patel K. R., Lau E. H., Wright B. J. Differential uptake of liposomes varying in size and lipid composition by parenchymal and kupffer cells of mouse liver. Life Sci. 1982 Nov 8;31(19):2061–2071. doi: 10.1016/0024-3205(82)90098-4. [DOI] [PubMed] [Google Scholar]
  24. Rahman Y. E., Cerny E. A., Tollaksen S. L., Wright B. J., Nance S. L., Thomson J. F. Liposome-encapsulated actinomycin D: potential in cancer chemotherapy. Proc Soc Exp Biol Med. 1974 Sep;146(4):1173–1176. doi: 10.3181/00379727-146-38268. [DOI] [PubMed] [Google Scholar]
  25. Rahman Y. E., Rosenthal M. W., Cerny E. A. Intracellular plutonium: removal by liposome-encapsulated chelating agent. Science. 1973 Apr 20;180(4083):300–302. doi: 10.1126/science.180.4083.300. [DOI] [PubMed] [Google Scholar]
  26. Rahman Y. E., Rosenthal M. W., Cerny E. A., Moretti E. S. Preparation and prolonged tissue retention of liposome-encapsulated chelating agents. J Lab Clin Med. 1974 Apr;83(4):640–647. [PubMed] [Google Scholar]
  27. Saba T. M. Physiology and physiopathology of the reticuloendothelial system. Arch Intern Med. 1970 Dec;126(6):1031–1052. [PubMed] [Google Scholar]
  28. Schroit A. J., Fidler I. J. Effects of liposome structure and lipid composition on the activation of the tumoricidal properties of macrophages by liposomes containing muramyl dipeptide. Cancer Res. 1982 Jan;42(1):161–167. [PubMed] [Google Scholar]
  29. Shek P. N., Sabiston B. H. Immune response mediated by liposome-associated protein antigens. I. Potentiation of the plaque-forming cell response. Immunology. 1982 Feb;45(2):349–356. [PMC free article] [PubMed] [Google Scholar]
  30. Souhami R. L., Patel H. M., Ryman B. E. The effect of reticuloendothelial blockade on the blood clearance and tissue distribution of liposomes. Biochim Biophys Acta. 1981 May 18;674(3):354–371. doi: 10.1016/0304-4165(81)90366-4. [DOI] [PubMed] [Google Scholar]
  31. Souhami R. L. The effect of colloidal carbon on the organ distribution of sheep red cells and the immune response. Immunology. 1972 Apr;22(4):685–694. [PMC free article] [PubMed] [Google Scholar]
  32. Tanaka T., Taneda K., Kobayashi H., Okumura K., Muranishi S., Sezaki H. Application of liposomes to the pharmaceutical modification of the distribution characteristics of drugs in the rat. Chem Pharm Bull (Tokyo) 1975 Dec;23(12):3069–3074. doi: 10.1248/cpb.23.3069. [DOI] [PubMed] [Google Scholar]
  33. Wu P. S., Tin G. W., Baldeschwieler J. D. Phagocytosis of carbohydrate-modified phospholipid vesicles by macrophage. Proc Natl Acad Sci U S A. 1981 Apr;78(4):2033–2037. doi: 10.1073/pnas.78.4.2033. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Yatvin M. B., Kreutz W., Horwitz B. A., Shinitzky M. pH-sensitive liposomes: possible clinical implications. Science. 1980 Dec 12;210(4475):1253–1255. doi: 10.1126/science.7434025. [DOI] [PubMed] [Google Scholar]
  35. Yatvin M. B., Weinstein J. N., Dennis W. H., Blumenthal R. Design of liposomes for enhanced local release of drugs by hyperthermia. Science. 1978 Dec 22;202(4374):1290–1293. doi: 10.1126/science.364652. [DOI] [PubMed] [Google Scholar]
  36. van Rooijen N., van Nieuwmegen R. Liposomes in immunology: evidence that their adjuvant effect results from surface exposition of the antigens. Cell Immunol. 1980 Feb;49(2):402–407. doi: 10.1016/0008-8749(80)90043-x. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES