Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1985 Sep;82(18):6080–6084. doi: 10.1073/pnas.82.18.6080

Human placental alkaline phosphatase in liver and intestine.

E Garattini, J Margolis, E Heimer, A Felix, S Udenfriend
PMCID: PMC390703  PMID: 3862120

Abstract

Three distinct forms of human alkaline phosphatase, presumably isozymes, are known, each apparently associated with a specific tissue. These are placental, intestinal, and liver (kidney and bone). We have used a specific immunoassay and HPLC to show that placental alkaline phosphatase is also present in extracts of liver and intestine in appreciable amounts.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ezra E., Blacher R., Udenfriend S. Purification and partial sequencing of human placental alkaline phosphatase. Biochem Biophys Res Commun. 1983 Nov 15;116(3):1076–1083. doi: 10.1016/s0006-291x(83)80252-6. [DOI] [PubMed] [Google Scholar]
  2. Gogolin K. J., Wray L. K., Slaughter C. A., Harris H. A monoclonal antibody that reacts with nonallelic enzyme glycoproteins. Science. 1982 Apr 2;216(4541):59–61. doi: 10.1126/science.6175022. [DOI] [PubMed] [Google Scholar]
  3. Kitagawa T., Aikawa T. Enzyme coupled immunoassay of insulin using a novel coupling reagent. J Biochem. 1976 Jan;79(1):233–236. doi: 10.1093/oxfordjournals.jbchem.a131053. [DOI] [PubMed] [Google Scholar]
  4. McKenna M. J., Hamilton T. A., Sussman H. H. Comparison of human alkaline phosphatase isoenzymes. Structural evidence for three protein classes. Biochem J. 1979 Jul 1;181(1):67–73. doi: 10.1042/bj1810067. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Mulivor R. A., Hannig V. L., Harris H. Developmental change in human intestinal alkaline phosphatase. Proc Natl Acad Sci U S A. 1978 Aug;75(8):3909–3912. doi: 10.1073/pnas.75.8.3909. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Mulivor R. A., Plotkin L. I., Harris H. Differential inhibition of the products of the human alkaline phosphatase loci. Ann Hum Genet. 1978 Jul;42(1):1–13. doi: 10.1111/j.1469-1809.1978.tb00927.x. [DOI] [PubMed] [Google Scholar]
  7. Seargeant L. E., Stinson R. A. Evidence that three structural genes code for human alkaline phosphatases. Nature. 1979 Sep 13;281(5727):152–154. doi: 10.1038/281152a0. [DOI] [PubMed] [Google Scholar]
  8. Slaughter C. A., Gogolin K. J., Coseo M. C., Meyer L. J., Lesko J., Harris H. Discrimination of human placental alkaline phosphatase allelic variants by monoclonal antibodies. Am J Hum Genet. 1983 Jan;35(1):1–20. [PMC free article] [PubMed] [Google Scholar]
  9. Trépanier J. M., Seargeant L. E., Stinson R. A. Affinity purification and some molecular properties of human liver alkaline phosphatase. Biochem J. 1976 Jun 1;155(3):653–660. doi: 10.1042/bj1550653. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES