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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1985 Oct;82(19):6409–6413. doi: 10.1073/pnas.82.19.6409

Pure brain-derived acidic fibroblast growth factor is a potent angiogenic vascular endothelial cell mitogen with sequence homology to interleukin 1.

K A Thomas, M Rios-Candelore, G Giménez-Gallego, J DiSalvo, C Bennett, J Rodkey, S Fitzpatrick
PMCID: PMC390725  PMID: 2413439

Abstract

Pure bovine brain-derived acidic fibroblast growth factor is a very potent mitogen for vascular endothelial cells in culture and, in the presence of heparin, induces blood vessel growth in vivo. Partial amino acid sequence determinations confirm that this mitogen is a unique protein having amino acid sequence homology with human interleukin 1.

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