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. 1996 Jun 25;93(13):6610–6615. doi: 10.1073/pnas.93.13.6610

Gadolinium(III) texaphyrin: a tumor selective radiation sensitizer that is detectable by MRI.

S W Young 1, F Qing 1, A Harriman 1, J L Sessler 1, W C Dow 1, T D Mody 1, G W Hemmi 1, Y Hao 1, R A Miller 1
PMCID: PMC39073  PMID: 8692865

Abstract

Gadolinium(III) texaphyrin (Gd-tex2+) is representative of a new class of radiation sensitizers detectable by magnetic resonance imaging (MRI). This porphyrin-like complex has a high electron affinity [E1/2 (red.) approximately = -0.08 V versus normal hydrogen electrode] and forms a long-lived pi-radical cation upon exposure to hydrated electrons, reducing ketyl radicals, or superoxide ions. Consistent with these chemical findings, Gd-tex2+ was found to be an efficient radiation sensitizer in studies carried out with HT29 cells in in vitro as well as in in vivo single and multifraction irradiation studies with a murine mammary carcinoma model. Selective localization of Gd-tex2+ in tumors was confirmed by MRI scanning.

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