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. 1996 Jun 25;93(13):6635–6640. doi: 10.1073/pnas.93.13.6635

A novel function for Myc: inhibition of C/EBP-dependent gene activation.

S Mink 1, B Mutschler 1, R Weiskirchen 1, K Bister 1, K H Klempnauer 1
PMCID: PMC39078  PMID: 8692870

Abstract

We have investigated the effect of the v-Myc oncoprotein on gene expression in myelomonocytic cells. We find that v-Myc dramatically down-regulates the expression of myelomonocytic-specific genes, such as the chicken mim-1 and lysozyme genes, both of which are known targets for C/EBP transcription factors. We present evidence that Myc downregulates these genes by inhibiting the function of C/EBP transcription factors. Detailed examination of the inhibitory mechanism shows that amino-terminal sequences of v-Myc, but not its DNA-binding domain, are required for the suppression of C/EBP-dependent transactivation. Our findings identify a new function for Myc and reveal a novel mechanism by which Myc affects the expression of other genes.

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Selected References

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