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. Author manuscript; available in PMC: 2014 Nov 26.
Published in final edited form as: Biochemistry. 2013 Nov 14;52(47):8406–8419. doi: 10.1021/bi400704d

Figure 8. 1G8-14 and 2F11-14 aptamers have multiple binding modes.

Figure 8

VP35 aptamers display two binding modes that include a single high affinity binding site and multiple dsRNA binding sites. At low eVP35 IID WTconcentrations or when binding to key dsRNA binding mutant R312A, only the high affinity site is occupied. At higher concentrations of eVP35 IID WT additional binding events occur via the dsRNA binding mode.