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. 1985 Jul;82(14):4732–4735. doi: 10.1073/pnas.82.14.4732

Inherently radioresistant cells exist in some human tumors.

R R Weichselbaum, W Dahlberg, J B Little
PMCID: PMC390978  PMID: 3860821

Abstract

We investigated the survival of 29 human tumor cell lines after treatment with ionizing radiation during exponential growth. The radiosensitivity of 20 tumor cell lines was within the range of normal fibroblasts. However, 9 cell lines derived from radio-incurable tumors appeared inherently radioresistant. When the ability to repair potentially lethal x-ray damage was studied in plateau phase cultures, some tumor cell lines derived from radio-incurable tumors were more efficient in this process. These results indicate that the presence of radioresistant and/or repair-proficient cells, which exist in some human tumors, may be responsible for failure to obtain local control following therapeutic x-ray treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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