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. Author manuscript; available in PMC: 2014 Mar 19.
Published in final edited form as: Nature. 2013 Aug 25;501(7467):444–448. doi: 10.1038/nature12487

Figure 1. Structure of the eag domain-CNBHD complex of mEAG1.

Figure 1

a, Cartoon of a cross section of a KCNH channel. Transmembrane domains are in grey, the amino-terminal eag domains are in green, the C-linkers are in orange and the CNBHD domains in blue. The intrinsic ligand motifs are highlighted in yellow, and the post-CNBHD in red. b, Structure of the eag domain-CNBHD complex. Color corresponds to panel a. c, Disease-causing mutations at the interface of eag domain and CNBHD. LQT2 mutations are shown in yellow. Cancer-associated mutations are shown in red. Y44 is involved in both LQT2 and cancer and is shown in red.