Table 1.
Patient Characteristics stratified by brain metastases development as a first site of recurrence
| No Brain Metastases (N=2333) | Yes Brain Metastases (N=115) | ||||
|---|---|---|---|---|---|
|
| |||||
| N | % | N | % | P | |
|
| |||||
| Age, Median | 50 | 47 | |||
| Age | |||||
| < 50 | 1124 | 48.2 | 65 | 56.5 | |
| ≥ 50 | 1209 | 51.8 | 50 | 43.5 | .08 |
| Menopausal Status | |||||
| Pre | 970 | 41.8 | 53 | 46.1 | |
| Post | 1348 | 58.2 | 62 | 53.9 | .37 |
| Race | |||||
| White | 1514 | 64.9 | 82 | 71.3 | |
| Black | 422 | 18.1 | 15 | 13.0 | |
| Other | 397 | 17.0 | 18 | 15.7 | .31 |
| Histology | |||||
| Invasive ductal | 2108 | 91.6 | 108 | 93.9 | |
| Invasive lobular | 21 | 0.9 | 2 | 1.7 | |
| Mixed (ductal/lobular) | 24 | 1.0 | 2 | 1.7 | |
| Other | 149 | 6.5 | 3 | 2.6 | .27 |
| Stage | |||||
| I | 600 | 25.7 | 16 | 13.9 | |
| II | 1205 | 51.7 | 51 | 44.3 | |
| III | 528 | 22.6 | 48 | 41.7 | <.0001 |
| Nuclear Grade | |||||
| I | 13 | 0.6 | 0 | 0.0 | |
| II | 193 | 8.5 | 6 | 5.3 | |
| III | 2056 | 90.9 | 107 | 94.7 | .34 |
| Lymphovascular invasion | |||||
| Negative | 1642 | 72.0 | 66 | 58.9 | |
| Positive | 637 | 28.0 | 46 | 41.1 | .003 |
| Breast surgery | |||||
| Breast conservation | 1120 | 48.8 | 42 | 38.2 | |
| Mastectomy | 1150 | 50.2 | 68 | 61.8 | |
| None | 23 | 1.0 | 0 | 0.0 | .04 |
| Taxane | |||||
| No | 772 | 33.5 | 32 | 27.8 | |
| Yes | 1531 | 66.5 | 83 | 72.2 | .21 |
| Anthracycline | |||||
| No | 446 | 19.4 | 20 | 17.4 | |
| Yes | 1855 | 80.6 | 95 | 82.6 | .60 |
| Adjuvant radiation | |||||
| No | 831 | 35.6 | 38 | 33.0 | |
| Yes | 1502 | 64.4 | 77 | 67.0 | .57 |