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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Anesthesiology. 2014 Jan;120(1):76–85. doi: 10.1097/ALN.0000000000000025

Figure 2. Immature muscle acetylcholine receptors (AChRs) do not contribute to neurotransmission.

Figure 2

At the end of the waglerin-1 study, the conotoxin, αA-OIVA totaling 17.0 ± 0.25 μg/g was administered and caused minimal changes (≤ 1%) in twitch tension on the immobilized side. On the contralateral side the 99% twitch inhibition after waglerin-1 did not change after αA-OIVA (Data not shown). The subsequent administration of α-bungarotoxin (αBTX) (0.33 ± 0.06 μg/g) caused ≥ 97% twitch depression on the immobilized side, indicating that an approximate 20% of the twitch height is maintained by αBTX-sensitive nicotinic AChRs. Data are presented as percent of immobilized side.