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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1985 Sep;82(18):6335–6339. doi: 10.1073/pnas.82.18.6335

Morphology and distribution of tyrosine hydroxylase-like immunoreactive neurons in the cat retina.

C W Oyster, E S Takahashi, M Cilluffo, N C Brecha
PMCID: PMC391048  PMID: 2863820

Abstract

In cat retina, antisera directed against tyrosine hydroxylase (tyrosine 3-monooxygenase; EC 1.14.16.2) labeled three morphologically distinct classes of neurons; amacrine cells, displaced amacrine cells, and interplexiform cells. These three cell populations differed not only in their morphologies but also in their numbers, densities, and retinal distributions. Insofar as tyrosine hydroxylase-like immunoreactivity is associated with dopaminergic neurons, these observations suggest that the dopamine system in cat retina is morphologically heterogeneous and that the cat retina contains functional subdivisions based on the different distributions of specific cell populations.

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Selected References

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  1. Amthor F. R., Oyster C. W., Takahashi E. S. Quantitative morphology of rabbit retinal ganglion cells. Proc R Soc Lond B Biol Sci. 1983 Feb 22;217(1208):341–355. doi: 10.1098/rspb.1983.0014. [DOI] [PubMed] [Google Scholar]
  2. BISHOP P. O., KOZAK W., VAKKUR G. J. Some quantitative aspects of the cat's eye: axis and plane of reference, visual field co-ordinates and optics. J Physiol. 1962 Oct;163:466–502. doi: 10.1113/jphysiol.1962.sp006990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Boycott B. B., Dowling J. E., Fisher S. K., Kolb H., Laties A. M. Interplexiform cells of the mammalian retina and their comparison with catecholamine-containing retinal cells. Proc R Soc Lond B Biol Sci. 1975 Dec 2;191(1104):353–368. doi: 10.1098/rspb.1975.0133. [DOI] [PubMed] [Google Scholar]
  4. Brecha N. C., Oyster C. W., Takahashi E. S. Identification and characterization of tyrosine hydroxylase immunoreactive amacrine cells. Invest Ophthalmol Vis Sci. 1984 Jan;25(1):66–70. [PubMed] [Google Scholar]
  5. Dowling J. E., Ehinger B., Florén I. Fluorescence and electron microscopical observations on the amine-accumulating neurons of the cebus monkey retina. J Comp Neurol. 1980 Aug 15;192(4):665–685. doi: 10.1002/cne.901920404. [DOI] [PubMed] [Google Scholar]
  6. Dowling J. E., Ehinger B. The interplexiform cell system. I. Synapses of the dopaminergic neurons of the goldfish retina. Proc R Soc Lond B Biol Sci. 1978 Apr 13;201(1142):7–26. doi: 10.1098/rspb.1978.0030. [DOI] [PubMed] [Google Scholar]
  7. Ehinger B. Neurotransmitter systems in the retina. Retina. 1982;2(4):305–321. [PubMed] [Google Scholar]
  8. Hadjiconstantinou M., Mariani A. P., Panula P., Joh T. H., Neff N. H. Immunohistochemical evidence for epinephrine-containing retinal amacrine cells. Neuroscience. 1984 Oct;13(2):547–551. doi: 10.1016/0306-4522(84)90247-1. [DOI] [PubMed] [Google Scholar]
  9. Hughes A. A quantitative analysis of the cat retinal ganglion cell topography. J Comp Neurol. 1975 Sep;163(1):107–128. doi: 10.1002/cne.901630107. [DOI] [PubMed] [Google Scholar]
  10. Hughes A. A supplement to the cat schematic eye. Vision Res. 1976;16(2):149–154. doi: 10.1016/0042-6989(76)90091-2. [DOI] [PubMed] [Google Scholar]
  11. Jensen R. J., Daw N. W. Effects of dopamine antagonists on receptive fields of brisk cells and directionally selective cells in the rabbit retina. J Neurosci. 1984 Dec;4(12):2972–2985. doi: 10.1523/JNEUROSCI.04-12-02972.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kolb H., Nelson R., Mariani A. Amacrine cells, bipolar cells and ganglion cells of the cat retina: a Golgi study. Vision Res. 1981;21(7):1081–1114. doi: 10.1016/0042-6989(81)90013-4. [DOI] [PubMed] [Google Scholar]
  13. Kramer S. G. Dopamine: A retinal neurotransmitter. I. Retinal uptake, storage, and light-stimulated release of H3-dopamine in vivo. Invest Ophthalmol. 1971 Jun;10(6):438–452. [PubMed] [Google Scholar]
  14. Mariani A. P., Kolb H., Nelson R. Dopamine-containing amacrine cells of rhesus monkey retina parallel rods in spatial distribution. Brain Res. 1984 Nov 19;322(1):1–7. doi: 10.1016/0006-8993(84)91174-0. [DOI] [PubMed] [Google Scholar]
  15. Nakamura Y., McGuire B. A., Sterling P. Interplexiform cell in cat retina: identification by uptake of gamma-[3H]aminobutyric acid and serial reconstruction. Proc Natl Acad Sci U S A. 1980 Jan;77(1):658–661. doi: 10.1073/pnas.77.1.658. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Negishi K., Nakamura T., Hayashi T. Spatial density of catecholaminergic cells in the carp retina. Exp Eye Res. 1980 Dec;31(6):711–719. doi: 10.1016/s0014-4835(80)80055-8. [DOI] [PubMed] [Google Scholar]
  17. Nguyen-Legros J., Berger B., Vigny A., Alvarez C. Tyrosine hydroxylase-like immunoreactive interplexiform cells in the rat retina. Neurosci Lett. 1981 Dec 23;27(3):255–259. doi: 10.1016/0304-3940(81)90439-0. [DOI] [PubMed] [Google Scholar]
  18. Nguyen-Legros J., Botteri C., Phuc L. H., Vigny A., Gay M. Morphology of primate's dopaminergic amacrine cells as revealed by TH-like immunoreactivity on retinal flat-mounts. Brain Res. 1984 Mar 12;295(1):145–153. doi: 10.1016/0006-8993(84)90825-4. [DOI] [PubMed] [Google Scholar]
  19. Pourcho R. G. Autoradiographic localization of [3H]muscimol in the cat retina. Brain Res. 1981 Jun 29;215(1-2):187–199. doi: 10.1016/0006-8993(81)90501-1. [DOI] [PubMed] [Google Scholar]
  20. Pourcho R. G. Dopaminergic amacrine cells in the cat retina. Brain Res. 1982 Dec 2;252(1):101–109. doi: 10.1016/0006-8993(82)90982-9. [DOI] [PubMed] [Google Scholar]
  21. Stephens J. K., Masserano J. M., Vulliet P. R., Weiner N., Nakane P. K. Immunocytochemical localization of tyrosine hydroxylase in rat adrenal medulla by the peroxidase labeled antibody method: effects of enzyme activation on ultrastructural distribution of the enzyme. Brain Res. 1981 Mar 30;209(2):339–354. doi: 10.1016/0006-8993(81)90158-x. [DOI] [PubMed] [Google Scholar]
  22. Stone J. The number and distribution of ganglion cells in the cat's retina. J Comp Neurol. 1978 Aug 15;180(4):753–771. doi: 10.1002/cne.901800407. [DOI] [PubMed] [Google Scholar]
  23. Thier P., Alder V. Action of iontophoretically applied dopamine on cat retinal ganglion cells. Brain Res. 1984 Jan 30;292(1):109–121. doi: 10.1016/0006-8993(84)90895-3. [DOI] [PubMed] [Google Scholar]
  24. Törk I., Stone J. Morphology of catecholamine-containing amacrine cells in the cat's retina, as seen in retinal whole mounts. Brain Res. 1979 Jun 22;169(2):261–273. doi: 10.1016/0006-8993(79)91029-1. [DOI] [PubMed] [Google Scholar]
  25. Versaux-Botteri C., Nguyen-Legros J., Vigny A., Raoux N. Morphology, density and distribution of tyrosine hydroxylase-like immunoreactive cells in the retina of mice. Brain Res. 1984 May 28;301(1):192–197. doi: 10.1016/0006-8993(84)90423-2. [DOI] [PubMed] [Google Scholar]

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