Table 2.
Analytes associated with inflammation or tissue damage with a four-fold or greater change in concentration as a result of JEV SA14-14-2 infection in AG129 mice.
| Serum | Brain | Spleen | ||
|---|---|---|---|---|
| Pro-inflammatory | ||||
| CRP | C-Reactive Protein Mouse | ↑ | ↑ | ↑ |
| CD40 | CD40 | ↑ | ||
| CD40L | CD40 Ligand | ↑ | ||
| Fibrinogen | ↑ | ↑ | ||
| GM-CSF | Granulocyte-Macrophage Colony Stimulating Factor | ↑ | ||
| KC/GRO | Growth-Regulated Alpha Protein | ↑ | ↑ | ↑ |
| IFNγ | Interferon gamma | ↑ | ↑ | |
| IP-10 | Interferon gamma induced protein | ↑ | ↑ | ↑ |
| IL-1α | Interleukin-1 alpha | ↑ | ↑ | |
| IL-1β | Interleukin-1 beta | ↑ | ||
| IL-6 | Interleukin-6 | ↑ | ↑ | ↑ |
| IL-11 | Interleukin-11 | ↑ | ||
| IL-12p70 | Interleukin-12 subunit p70 | ↑ | ||
| IL-18 | Interleukin 18 | ↑ | ||
| MDC | Macrophage-derived chemokine | ↑ | ↑ | ↑ |
| MIP-1 α | Macrophage Inflammatory protein-1 alpha | ↑ | ||
| MIP-1 β | Macrophage Inflammatory protein-1 beta | ↑ | ↑ | |
| MIP-1 γ | Macrophage Inflammatory protein-1 gamma | ↑ | ↑ | |
| MIP-2 | Macrophage inflammatory protein-2 | ↑ | ↑ | ↑ |
| MIP-3β | Macrophage inflammatory protein 3 beta | ↑ | ||
| MCP-1 | Monocyte chemotactic protein-1 | ↑ | ↑ | ↑ |
| MCP-3 | Monocyte chemotactic protein-3 | ↑ | ↑ | ↑ |
| MCP-5 | Monocyte chemotactic protein-5 | ↑ | ↑ | ↑ |
| OSM | Oncostatin-M | ↑ | ||
| RANTES | T-cell Specific Protein RANTES | ↑ | ↑ | ↑ |
| TNFα | Tumor Necrosis Factor alpha | ↑ | ||
| Anti-inflammatory | ||||
| IL-10 | Interleukin-10 | ↑ | ↑ | |
| TMP-1 | Tissue Inhibitor of Metalloproteinases | ↑ | ↑ | ↑ |
| Tissue damage | ||||
| IL-7 | Interleukin-7 | ↑ | ↑ | |
| MMP-9 | Matrix Metalloproteinase-9 | ↑ | ||
| MPO | Myeloperoxidase | ↑ | ↑ | ↑ |
| Myoglobin | ↓ | |||
| PAI-1 | Plasminogen Activator Inhibitor-1 | ↑ | ↑ | ↑ |