Abstract
The specificity of the DNA product of the RNA-dependent DNA polymerase found in C-type virions was analyzed by reciprocal hybridization with RNA from viruses of mouse, hamster, cat, and viper. These tests revealed a clear species specificity for the DNA product with no detectable interspecies hybridization.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Baltimore D. RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature. 1970 Jun 27;226(5252):1209–1211. doi: 10.1038/2261209a0. [DOI] [PubMed] [Google Scholar]
- Fujinaga K., Parsons J. T., Beard J. W., Beard D., Green M. Mechanism of carcinogenesis by RNA tumor viruses. 3. Formation of RNA, DNA complex and duplex DNA molecules by the DNA polymerase (s) of avian myeloblastosis virus. Proc Natl Acad Sci U S A. 1970 Nov;67(3):1432–1439. doi: 10.1073/pnas.67.3.1432. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gilden R. V., Lee Y. K., Oroszlan S., Walker J. L., Huebner R. J. Reptilian C-type virus: biophysical, biological, and immunological properties. Virology. 1970 May;41(1):187–190. doi: 10.1016/0042-6822(70)90069-3. [DOI] [PubMed] [Google Scholar]
- Hatanaka M., Huebner R. J., Gilden R. V. DNA polymerase activity associated with RNA tumor viruses. Proc Natl Acad Sci U S A. 1970 Sep;67(1):143–147. doi: 10.1073/pnas.67.1.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kelloff G., Huebner R. J., Lee Y. K., Toni R., Gilden R. Hamster-tropic sarcomagenic and nonsarcomagenic viruses derived from hamster tumors induced by the Gross pseudotype of Moloney sarcoma virus. Proc Natl Acad Sci U S A. 1970 Feb;65(2):310–317. doi: 10.1073/pnas.65.2.310. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCarthy B. J., Church R. B. The specificity of molecular hybridization reactions. Annu Rev Biochem. 1970;39:131–150. doi: 10.1146/annurev.bi.39.070170.001023. [DOI] [PubMed] [Google Scholar]
- Rokutanda M., Rokutanda H., Green M., Fujinaga K., Ray R. K., Gurgo C. Formation of viral RNA-DNA hybrid molecules by the DNA polymerase of sarcoma-leukaemia viruses. Nature. 1970 Sep 5;227(5262):1026–1028. doi: 10.1038/2271026a0. [DOI] [PubMed] [Google Scholar]
- Scolnick E. M., Aaronson S. A., Todaro G. J. DNA synthesis by RNA-containing tumor viruses. Proc Natl Acad Sci U S A. 1970 Oct;67(2):1034–1041. doi: 10.1073/pnas.67.2.1034. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Spiegelman S., Burny A., Das M. R., Keydar J., Schlom J., Travnicek M., Watson K. Characterization of the products of DNA-directed DNA polymerases in oncogenic RNA viruses. Nature. 1970 Aug 8;227(5258):563–567. doi: 10.1038/227563a0. [DOI] [PubMed] [Google Scholar]
- Spiegelman S., Burny A., Das M. R., Keydar J., Schlom J., Travnicek M., Watson K. DNA-directed DNA polymerase activity in oncogenic RNA viruses. Nature. 1970 Sep 5;227(5262):1029–1031. doi: 10.1038/2271029a0. [DOI] [PubMed] [Google Scholar]
- Temin H. M., Mizutani S. RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature. 1970 Jun 27;226(5252):1211–1213. doi: 10.1038/2261211a0. [DOI] [PubMed] [Google Scholar]
- Theilen G. H., Kawakami T. G., Rush J. D., Munn R. J. Replication of cat leukemia virus in cell suspension cultures. Nature. 1969 May 10;222(5193):589–590. doi: 10.1038/222589b0. [DOI] [PubMed] [Google Scholar]
- Zeigel R. F., Clark H. F. Electron microscopic observations on a "C"-type virus in cell cultures derived from a tumor-bearing viper. J Natl Cancer Inst. 1969 Nov;43(5):1097–1102. [PubMed] [Google Scholar]