Abstract
Amblyopia is a neuronal abnormality of vision that is often considered irreversible in adults. We found strong and significant improvement of Vernier acuity in human adults with naturally occurring amblyopia following practice. Learning was strongest at the trained orientation and did not transfer to an untrained task (detection), but it did transfer partially to the untrained eye (primarily at the trained orientation). We conclude that this perceptual learning reflects alterations in early neural processes that are localized beyond the site of convergence of the two eyes. Our results suggest a significant degree of plasticity in the visual system of adults with amblyopia.
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- Ball K., Sekuler R. Direction-specific improvement in motion discrimination. Vision Res. 1987;27(6):953–965. doi: 10.1016/0042-6989(87)90011-3. [DOI] [PubMed] [Google Scholar]
- Beard B. L., Levi D. M., Reich L. N. Perceptual learning in parafoveal vision. Vision Res. 1995 Jun;35(12):1679–1690. doi: 10.1016/0042-6989(94)00267-p. [DOI] [PubMed] [Google Scholar]
- Birnbaum M. H., Koslowe K., Sanet R. Success in ambylopia therapy as a function of age: a literature survey. Am J Optom Physiol Opt. 1977 May;54(5):269–275. [PubMed] [Google Scholar]
- Boothe R. G., Dobson V., Teller D. Y. Postnatal development of vision in human and nonhuman primates. Annu Rev Neurosci. 1985;8:495–545. doi: 10.1146/annurev.ne.08.030185.002431. [DOI] [PubMed] [Google Scholar]
- Chino Y. M., Kaas J. H., Smith E. L., 3rd, Langston A. L., Cheng H. Rapid reorganization of cortical maps in adult cats following restricted deafferentation in retina. Vision Res. 1992 May;32(5):789–796. doi: 10.1016/0042-6989(92)90021-a. [DOI] [PubMed] [Google Scholar]
- Chino Y. M., Smith E. L., 3rd, Yoshida K., Cheng H., Hamamoto J. Binocular interactions in striate cortical neurons of cats reared with discordant visual inputs. J Neurosci. 1994 Aug;14(8):5050–5067. doi: 10.1523/JNEUROSCI.14-08-05050.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fahle M., Edelman S. Long-term learning in vernier acuity: effects of stimulus orientation, range and of feedback. Vision Res. 1993 Feb;33(3):397–412. doi: 10.1016/0042-6989(93)90094-d. [DOI] [PubMed] [Google Scholar]
- Fiorentini A., Berardi N. Learning in grating waveform discrimination: specificity for orientation and spatial frequency. Vision Res. 1981;21(7):1149–1158. doi: 10.1016/0042-6989(81)90017-1. [DOI] [PubMed] [Google Scholar]
- Gilbert C. D., Wiesel T. N. Receptive field dynamics in adult primary visual cortex. Nature. 1992 Mar 12;356(6365):150–152. doi: 10.1038/356150a0. [DOI] [PubMed] [Google Scholar]
- Hess R. F., Holliday I. E. The spatial localization deficit in amblyopia. Vision Res. 1992 Jul;32(7):1319–1339. doi: 10.1016/0042-6989(92)90225-8. [DOI] [PubMed] [Google Scholar]
- Hubel D. H., Wiesel T. N. Receptive fields and functional architecture of monkey striate cortex. J Physiol. 1968 Mar;195(1):215–243. doi: 10.1113/jphysiol.1968.sp008455. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KUPFER C. Treatment of amblyopia exanopsia in adults; a preliminary report of seven cases. Am J Ophthalmol. 1957 Jun;43(6):918–922. doi: 10.1016/0002-9394(57)91795-6. [DOI] [PubMed] [Google Scholar]
- Kapadia M. K., Gilbert C. D., Westheimer G. A quantitative measure for short-term cortical plasticity in human vision. J Neurosci. 1994 Jan;14(1):451–457. doi: 10.1523/JNEUROSCI.14-01-00451.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karni A., Sagi D. The time course of learning a visual skill. Nature. 1993 Sep 16;365(6443):250–252. doi: 10.1038/365250a0. [DOI] [PubMed] [Google Scholar]
- Karni A., Sagi D. Where practice makes perfect in texture discrimination: evidence for primary visual cortex plasticity. Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4966–4970. doi: 10.1073/pnas.88.11.4966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levi D. M., Harwerth R. S., Smith E. L., 3rd Humans deprived of normal binocular vision have binocular interactions tuned to size and orientation. Science. 1979 Nov 16;206(4420):852–854. doi: 10.1126/science.493988. [DOI] [PubMed] [Google Scholar]
- Levi D. M., Klein S. A., Wang H. Amblyopic and peripheral vernier acuity: a test-pedestal approach. Vision Res. 1994 Dec;34(24):3265–3292. doi: 10.1016/0042-6989(94)90065-5. [DOI] [PubMed] [Google Scholar]
- Levi D. M., Klein S. Hyperacuity and amblyopia. Nature. 1982 Jul 15;298(5871):268–270. doi: 10.1038/298268a0. [DOI] [PubMed] [Google Scholar]
- McKee S. P., Westheimer G. Improvement in vernier acuity with practice. Percept Psychophys. 1978 Sep;24(3):258–262. doi: 10.3758/bf03206097. [DOI] [PubMed] [Google Scholar]
- Poggio T., Fahle M., Edelman S. Fast perceptual learning in visual hyperacuity. Science. 1992 May 15;256(5059):1018–1021. doi: 10.1126/science.1589770. [DOI] [PubMed] [Google Scholar]
- Poggio T., Fahle M., Edelman S. Fast perceptual learning in visual hyperacuity. Science. 1992 May 15;256(5059):1018–1021. doi: 10.1126/science.1589770. [DOI] [PubMed] [Google Scholar]
- Polat U., Sagi D. Spatial interactions in human vision: from near to far via experience-dependent cascades of connections. Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1206–1209. doi: 10.1073/pnas.91.4.1206. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Saarinen J., Levi D. M. Orientation anisotropy in vernier acuity. Vision Res. 1995 Sep;35(17):2449–2461. [PubMed] [Google Scholar]
- Saarinen J., Levi D. M. Perceptual learning in vernier acuity: what is learned? Vision Res. 1995 Feb;35(4):519–527. doi: 10.1016/0042-6989(94)00141-8. [DOI] [PubMed] [Google Scholar]
- Schoups A. A., Vogels R., Orban G. A. Human perceptual learning in identifying the oblique orientation: retinotopy, orientation specificity and monocularity. J Physiol. 1995 Mar 15;483(Pt 3):797–810. doi: 10.1113/jphysiol.1995.sp020623. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wick B., Wingard M., Cotter S., Scheiman M. Anisometropic amblyopia: is the patient ever too old to treat? Optom Vis Sci. 1992 Nov;69(11):866–878. doi: 10.1097/00006324-199211000-00006. [DOI] [PubMed] [Google Scholar]
- Zohary E., Celebrini S., Britten K. H., Newsome W. T. Neuronal plasticity that underlies improvement in perceptual performance. Science. 1994 Mar 4;263(5151):1289–1292. doi: 10.1126/science.8122114. [DOI] [PubMed] [Google Scholar]
- von Noorden G. K. Amblyopia: a multidisciplinary approach. Proctor lecture. Invest Ophthalmol Vis Sci. 1985 Dec;26(12):1704–1716. [PubMed] [Google Scholar]