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. 1985 Aug;82(16):5540–5544. doi: 10.1073/pnas.82.16.5540

Papillomavirus genomes in human cervical tumors: analysis of their transcriptional activity.

H Lehn, P Krieg, G Sauer
PMCID: PMC391158  PMID: 2991933

Abstract

Four of six human cervical carcinoma biopsies were shown to contain the DNA of the human papillomavirus type 16 (HPV-16) covalently linked with the tumor cell DNA. HPV-16-specific mRNA species were observed in only one of the four tumors. No such sequences were found in the three other specimens in conditions that permitted the detection of less than one mRNA molecule per cell. It is concluded that maintenance of the malignant nature of these cervical tumors does not depend on the continuous transcriptional activity of HPV-16.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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