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. 1971 Jan;68(1):187–191. doi: 10.1073/pnas.68.1.187

The Molecular Defect in a Protein (CRA) Found in γ1 Heavy Chain Disease, and Its Genetic Implications

E C Franklin 1,*, B Frangione 1,†
PMCID: PMC391192  PMID: 4100047

Abstract

A γ1 protein, designated CRA, found in heavy chain disease contains three inter-heavy disulfide bridges instead of the two normally found in γ1 immunoglobulin heavy chains. Almost the entire Fd fragment is missing. The NH2 terminal region is heterogeneous and contains carbohydrate; after 11 residues that do not resemble any of the known heavy-chain variable-region subclasses, normal synthesis seems to be resumed at the same amino acid residue as in another heavy-chain disease protein (ZUC). This finding raises the possibility that glutamic acid at position 216 represents the beginning of the Fe region, synthesized under the direction of another gene.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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