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. 1985 Oct;82(19):6657–6661. doi: 10.1073/pnas.82.19.6657

The human Thy-1 gene: structure and chromosomal location.

T Seki, N Spurr, F Obata, S Goyert, P Goodfellow, J Silver
PMCID: PMC391269  PMID: 2864690

Abstract

The human Thy-1 gene has been isolated and sequenced and compared to the rat and mouse Thy-1 genes. All three genes are organized in the same way: one exon encoding the majority of the signal peptide, another encoding the transmembrane segment, and a third encoding the remainder of the protein. One major structural difference between the human and rodent Thy-1 glycoproteins is that the former contains two instead of three glycosylation sites. RNA blot analysis of a human T-cell line expressing the T3 complex showed an absence of Thy-1 mRNA, excluding the possibility that Thy-1 represents one of the component chains of T3. The structural gene for human Thy-1 was localized to the long arm of chromosome 11 by nucleic acid hybridization to genomic DNA isolated from somatic cell hybrids.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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