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. 1985 Oct;82(20):7131–7135. doi: 10.1073/pnas.82.20.7131

Diversity among Purkinje cells in the monkey cerebellum.

V M Ingram, M P Ogren, C L Chatot, J M Gossels, B B Owens
PMCID: PMC391324  PMID: 3901012

Abstract

A monoclonal antibody (B1) produced against rat embryonic forebrain membranes shows specific and striking immunohistochemical staining of Purkinje cells in the monkey cerebellum in a pattern of broad parasagittal alternating bands of cells either possessing or lacking the B1 antigen. In addition, the neurons of the deep cerebellar nuclei and some neurons of the motor cortex and of the spinal cord also contain the B1 antigen. Neurons with the B1 antigen were also seen in the somatosensory cortex, the vestibular and cochlear nuclei, and the retina.

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Selected References

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  1. Chan-Palay V., Ito M., Tongroach P., Sakurai M., Palay S. Inhibitory effects of motilin, somatostatin, [Leu]enkephalin, [Met]enkephalin, and taurine on neurons of the lateral vestibular nucleus: interactions with gamma-aminobutyric acid. Proc Natl Acad Sci U S A. 1982 May;79(10):3355–3359. doi: 10.1073/pnas.79.10.3355. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chan-Palay V., Lin C. T., Palay S., Yamamoto M., Wu J. Y. Taurine in the mammalian cerebellum: demonstration by autoradiography with [3H]taurine and immunocytochemistry with antibodies against the taurine-synthesizing enzyme, cysteine-sulfinic acid decarboxylase. Proc Natl Acad Sci U S A. 1982 Apr;79(8):2695–2699. doi: 10.1073/pnas.79.8.2695. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chan-Palay V., Nilaver G., Palay S. L., Beinfeld M. C., Zimmerman E. A., Wu J. Y., O'Donohue T. L. Chemical heterogeneity in cerebellar Purkinje cells: existence and coexistence of glutamic acid decarboxylase-like and motilin-like immunoreactivities. Proc Natl Acad Sci U S A. 1981 Dec;78(12):7787–7791. doi: 10.1073/pnas.78.12.7787. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Chan-Palay V., Palay S. L., Wu J. Y. Sagittal cerebellar microbands of taurine neurons: immunocytochemical demonstration by using antibodies against the taurine-synthesizing enzyme cysteine sulfinic acid decarboxylase. Proc Natl Acad Sci U S A. 1982 Jul;79(13):4221–4225. doi: 10.1073/pnas.79.13.4221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hendrickson A. E., Ogren M. P., Vaughn J. E., Barber R. P., Wu J. Y. Light and electron microscopic immunocytochemical localization of glutamic acid decarboxylase in monkey geniculate complex: evidence for gabaergic neurons and synapses. J Neurosci. 1983 Jun;3(6):1245–1262. doi: 10.1523/JNEUROSCI.03-06-01245.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hockfield S., McKay R. D., Hendry S. H., Jones E. G. A surface antigen that identifies ocular dominance columns in the visual cortex and laminar features of the lateral geniculate nucleus. Cold Spring Harb Symp Quant Biol. 1983;48(Pt 2):877–889. doi: 10.1101/sqb.1983.048.01.090. [DOI] [PubMed] [Google Scholar]
  7. Hoffman S., Sorkin B. C., White P. C., Brackenbury R., Mailhammer R., Rutishauser U., Cunningham B. A., Edelman G. M. Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes. J Biol Chem. 1982 Jul 10;257(13):7720–7729. [PubMed] [Google Scholar]
  8. Marani E., Voogd J. An acetylcholinesterase band-pattern in the molecular layer of the cat cerebellum. J Anat. 1977 Nov;124(Pt 2):335–345. [PMC free article] [PubMed] [Google Scholar]
  9. Matthew W. D., Patterson P. H. The production of a monoclonal antibody that blocks the action of a neurite outgrowth-promoting factor. Cold Spring Harb Symp Quant Biol. 1983;48(Pt 2):625–631. doi: 10.1101/sqb.1983.048.01.066. [DOI] [PubMed] [Google Scholar]
  10. Nilaver G., Defendini R., Zimmerman E. A., Beinfeld M. C., O'Donohue T. L. Motilin in the Purkinje cell of the cerebellum. Nature. 1982 Feb 18;295(5850):597–598. doi: 10.1038/295597a0. [DOI] [PubMed] [Google Scholar]
  11. Obata K., Ito M., Ochi R., Sato N. Pharmacological properties of the postsynaptic inhibition by Purkinje cell axons and the action of gamma-aminobutyric acid on deiters NEURONES. Exp Brain Res. 1967;4(1):43–57. doi: 10.1007/BF00235216. [DOI] [PubMed] [Google Scholar]
  12. Pardue R. L., Brady R. C., Perry G. W., Dedman J. R. Production of monoclonal antibodies against calmodulin by in vitro immunization of spleen cells. J Cell Biol. 1983 Apr;96(4):1149–1154. doi: 10.1083/jcb.96.4.1149. [DOI] [PMC free article] [PubMed] [Google Scholar]

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