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. 1985 Nov;82(21):7399–7403. doi: 10.1073/pnas.82.21.7399

Use of anti-idiotypic antibodies to identify a receptor for the T-cell I-J determinant.

K Zupko, C Waltenbaugh, B Diamond
PMCID: PMC391352  PMID: 2932739

Abstract

In order to identify the molecule(s) interacting with the I-J determinant on suppressor T cells, we have generated two anti-idiotypic sera: one to monoclonal anti-I-Jd antibody and one to monoclonal anti-I-Jk antibody. These antisera specifically block suppressor T-cell function in a genetically restricted manner and have no effect on helper T-cell activation. Both recognize a marker on primary monocytes and B cells but not on T cells. A myeloma cell line bearing this marker has been identified. Therefore, these antisera may recognize a molecule on cells interacting with suppressor T cells that is involved in mediating suppressor T-cell activity. The relationship between the T-cell I-J determinant and the molecule identified by the anti-idiotype may be similar to the relationship between the receptor on helper T cells and Ia molecules.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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