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. 1985 Nov;82(21):7409–7413. doi: 10.1073/pnas.82.21.7409

Monoclonal antibody that defines human myoepithelium.

S H Dairkee, C Blayney, H S Smith, A J Hackett
PMCID: PMC391354  PMID: 2414776

Abstract

We have isolated a mouse monoclonal antibody that, upon immunohistochemical localization in frozen sections, displays specificity for human myoepithelial cells in the resting mammary gland, sweat glands, and salivary glands. Furthermore, this antibody was strongly and homogeneously reactive with frozen sections of 3 of 60 breast carcinoma specimens. Using immunolocalization techniques in conjunction with polyacrylamide gel electrophoresis, we have determined that the reactivity of this monoclonal antibody is directed toward a 51,000-dalton keratin polypeptide. The potential uses of this antibody in the prognosis of human mammary carcinoma and in understanding the role of the myoepithelium in development and differentiation are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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