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. 1985 Nov;82(22):7691–7695. doi: 10.1073/pnas.82.22.7691

Natural effector T lymphocytes in normal mice.

P Pereira, E L Larsson, L Forni, A Bandeira, A Coutinho
PMCID: PMC391399  PMID: 2933744

Abstract

The "natural" T-cell activity in normal unimmunized mice was studied. By double-parameter fluorescence-activated cell sorter analysis, it was found that 5-10% of all splenic Lyt-2+ and L3T4+ lymphocytes are large, of which more than half are in mitotic cycle. In contrast with small resting cells of the same phenotype, activated (large) T cells isolated from normal mice are functional effector cells: L3T4+ large cells induce normal B lymphocytes into proliferation and antibody secretion, while large Lyt-2+ cells efficiently suppress B-lymphocyte responses. No effector cell cytolytic activity could be detected among naturally activated T cells. The significance of these findings for the internal activity in the normal immune system is discussed.

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Selected References

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