Table 1.

Effects of new imidazolyl oxadiazole and triazole derivatives, and Indomethacin in the inhibition of abdominal constrictions induced by acetic acid (%0.6) in Mice

Compound	Constriction no. (mean ± SEM)1	Inhibition (%)2	Relative activity3
Vehicle control	59.67 ± 6.8	-	-
Indomethacin	13.50 ± 2.9	77.37	1***
7	44.33 ± 8.1	25.70	0.33
8	18.00 ± 3.7	69.83	0.90***
9	24.67 ± 5.5	58.65	0.76***
10	44.67 ± 2.8	25.14	0.32
11	23.83 ± 4.8	60.06	0.77***
12	24.33 ± 3.3	59.22	0.76***
13	17.67 ± 2.9	70.39	0.91***
14	ND4	-	-
15	15.50 ± 3.9	74.02	0.96***

¹All compounds were administered i.p. at the dose of 50 μmol/kg, number of animals in each group n = 6.

²% of inhibition obtained by comparison with vehicle control group.

³Analgesic activity relative to Indomethacin,^***P < 0.001 significant as compared to control.

⁴Not determined.