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. 2014 Jan 22;22(1):22. doi: 10.1186/2008-2231-22-22

Table 2.

Effects of new imidazolyl, oxadiazole and triazole derivatives 50(μmol/kg), and Indomethacin in the Carrageenan-induced rat paw edema

Compound Time (h)1 Volume variation (μL)2,3 % inhibition4
Vehicle control
 1
 1.53 ± 0.12
 -
2
 1.84 ± 0.17
 -
3
 2.22 ± 0.24
 -
4
 2.44 ± 0.26
 -
5
 2.11 ± 0.21
 -
Indomethacin
 1
 1.17 ± 0.01
 23.53
2
 1.35 ± 0.01
 26.63
3
 1.14 ± 0.02
 48.6**
4
 1.03 ± 0.02
 57.79***
5
 0.89 ± 0.01
 57.82***
8
 1
 1.60 ± 0.15
 -4.60
2
 1.82 ± 0.16
 1.10
3
 1.68 ± 0.18
 24.32
4
 1.53 ± 0.21
 37.30**
5
 1.19 ± 0.18
 43.60**
9
 1
 1.78 ± 0.14
 -16.34
2
 1.90 ± 0.14
 -3.26
3
 1.96 ± 0.16
 11.71
4
 1.78 ± 0.14
 27.05
5
 1.32 ± 0.07
 37.44*
11
 1
 1.95 ± 0.04
 -27.45
2
 2.11 ± 0.06
 -14.67
3
 1.82 ± 0.16
 18.02
4
 1.67 ± 0.20
 31.56*
5
 1.38 ± 0.22
 34.60*
12
 1
 1.27 ± 0.04
 16.99
2
 1.44 ± 0.06
 21.74
3
 1.49 ± 0.04
 32.88*
4
 1.45 ± 0.07
 40.57*
5
 1.22 ± 0.08
 42.18*
13
 1
 1.19 ± 0.16
 22.22
2
 1.70 ± 0.15
 7.60
3
 1.55 ± 0.12
 30.2*
4
 1.66 ± 0.11
 31.97*
5
 1.41 ± 0.10
 33.17*
14
 1
 1.39 ± 0.07
 9.15
2
 1.64 ± 0.10
 10.87
3
 1.90 ± 0.14
 14.41
4
 1.91 ± 0.11
 21.72
5
 1.69 ± 0.12
 19.90
15 1
 1.46 ± 0.08
 4.57
2
 1.78 ± 0.08
 3.26
3
 1.96 ± 0.10
 11.71
4
 2.02 ± 0.26
 17.21
5 1.98 ± 019 6.16

1Time after carrageenan injection (0.1 mg/paw), number of animals in each group n = 6.

2All compounds were administered i.p, at the dose of 50 μmol/kg.

3Volume variation is the difference between the volumes of paw pre and post of Carrageenan injection.

4% of inhibition obtained by comparison with vehicle control group, *P < 0.05 , **p < 0.01, ***p < 0.001 significant from control.