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. 2014 Jan 22;22(1):22. doi: 10.1186/2008-2231-22-22

Table 4.

Drug-likeness of target compounds predicted by Osiris Property Explorer tool in comparison with indomethacin and celecoxib

Compound
 Toxicity risk1
 cLogP Solubility MW Drug- likeness Drug-score
  M2 T3 I4 R5
7
 -
 -
 -
 -
 0.06
 -2.57
 165
 -1.88
 0.54
8
 -
 -
 -
 -
 0.92
 -2.2
 182
 0.87
 0.81
9
 -
 -
 -
 -
 0.25
 -2.12
 166
 -1.75
 0.55
10
 -
 -
 -
 -
 0.75
 -2.06
 181
 1.39
 0.86
11
 -
 -
 -
 -
 1.04
 -1.7
 195
 2.39
 0.94
12
 -
 -
 -
 -
 2.29
 -3.55
 257
 2.46
 0.82
13
 -
 -
 -
 -
 2.61
 -3.89
 271
 0.76
 0.68
14
 +
 ±
 -
 -
 2.19
 -3.56
 287
 0.7
 0.34
15
 -
 -
 -
 -
 2.35
 -3.86
 275
 0.7
 0.69
Indomethacin
 -
 -
 -
 -
 3.83
 -5.4
 357
 7.59
 0.57
Celecoxib - - - - 2.27 -5.4 365 -9.50 0.31

1Ranked according to: (-) no bad effect, (±) medium bad effect, (+) bad effect; 2 M, Mutagenic effect; 3 T, Tumorgenic effect; 4I, Irritating effect; 5R, Reproductive effect.