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. 1984 Aug;81(16):5223–5226. doi: 10.1073/pnas.81.16.5223

Dose-related effect of acetylsalicylic acid on replication of varicella zoster virus in vitro.

M A Walz-Cicconi, T H Weller
PMCID: PMC391670  PMID: 6089187

Abstract

Cultivation of human embryonic lung (HEL) cells in media containing acetylsalicylic acid (ASA) at 100 micrograms/ml and maintenance at this level after inoculation with either cell-free varicella zoster virus (VZV) or virus-infected cells resulted in a 2- to 4-fold increase in yields of cell-free virus released by sonication. The degree of enhancement was dependent upon multiplicity of infection and time of harvest. Enhanced viral yields were not consistently accompanied by an increase in the number of infected cells, nor was VZV plaque formation in HEL indicator cells significantly increased in the presence of ASA at 100 micrograms/ml. In the presence of ASA at 500-1000 micrograms/ml, VZV plaque formation was inhibited; this inhibition was partially reversible, depending on concentration and period of exposure to ASA. These findings may bear on the apparent association between ASA ingestion and the development of Reye syndrome after infection with varicella virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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