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. 1984 Sep;81(17):5360–5363. doi: 10.1073/pnas.81.17.5360

Neoplastic human fibroblast proteins are related to epidermal growth factor precursor.

S Burbeck, G Latter, E Metz, J Leavitt
PMCID: PMC391703  PMID: 6332316

Abstract

We report the amino acid composition of two polypeptides, p788 and p789. These polypeptides are reliable markers for neoplastic transformation in human fibroblasts. Their compositions are unusually rich in cysteine and serine. Because the recently reported amino acid sequence of mouse epidermal growth factor precursor (prepro-EGF) is also rich in those two amino acids and because the role of p788 and p789 as markers for neoplastic transformation is consistent with the fact that epidermal growth factor has been shown to play some role in transformation, we investigated the hypothesis that p788 and p789 are related to prepro-EGF. We compared the amino acid composition of p788 with that of all possible interior domains of prepro-EGF of appropriate length. We found that the composition of p788 is remarkably similar to that of residues 630-880 of prepro-EGF. The similarity is sufficiently strong to support the conclusion that it reflects amino acid sequence homology.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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