Figure 2. Profilin-1 heterozygote mice are protected against high fat diet-induced IR and inflammation. Under normal chow diet, adipose tissue stromal vascular fraction (SVF) contains regulatory T cells (Treg) and macrophages with a M2-like phenotype (green macrophages). Upon high fat diet, the SVF of wild-type mice exhibits increased accumulation of macrophages with a M1-like phenotype (red macrophages) and reduced frequency of Treg. Conversely, PfnHet mice showed a more heterogenous macrophage population (both red and green macrophages) and preserved Treg population. This is an oversimplified representation of the diverse array of macrophage subsets observed upon high fat diet.