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. 1984 Sep;81(18):5797–5801. doi: 10.1073/pnas.81.18.5797

Molecular model of ribosome frameshifting.

R B Weiss
PMCID: PMC391798  PMID: 6592589

Abstract

Normal tRNAs can cause two- and four-base translocation errors by mistranslating certain noncognate codons. Several cases have been reported that reveal the identities of the frameshift-provoking tRNAs--i.e., the shifty tRNAs--and the mRNA sequence encompassing the site of frameshifting--i.e., the shifty codons. Here, a striking uniformity between the anticodon loops of the shifty tRNAs and their shifty codons is described. Stable "offset" anti-codon X codon pairs are postulated for each of the shifty tRNA-shifty codon combinations. This offset anticodon X codon pair leads to two- and four-base translocations when viewed in terms of the reciprocating ratchet mechanism of translocation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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