Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1984 Oct;81(19):6250–6254. doi: 10.1073/pnas.81.19.6250

The survival of brain transplants is enhanced by extracts from injured brain.

M Nieto-Sampedro, S R Whittemore, D L Needels, J Larson, C W Cotman
PMCID: PMC391898  PMID: 6592613

Abstract

Fragments of rat embryo corpus striatum implanted into wound cavities in the cortex of neonatal rat hosts showed very poor survival when transplantation was performed immediately after the cavity was made. Consistent survival of the transplants was made possible by supplying the implant with extracts from the injured brain of neonatal rats. These extracts also supported in vitro survival of embryonic striatal neurons, suggesting that transplanted cells benefit from injury-induced neuronotrophic factors.

Full text

PDF
6250

Images in this article

6252Image
on p.6252
6253Image
on p.6253
6253Image
on p.6253
6253Image
on p.6253
6253Image
on p.6253

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arendash G. W., Gorski R. A. Enhancement of sexual behavior in female rats by neonatal transplantation of brain tissue from males. Science. 1982 Sep 24;217(4566):1276–1278. doi: 10.1126/science.7112132. [DOI] [PubMed] [Google Scholar]
  2. Azmitia E. C., Perlow M. J., Brennan M. J., Lauder J. M. Fetal raphe and hippocampal transplants into adult and aged C57BL/6N mice: a preliminary immunocytochemical study. Brain Res Bull. 1981 Dec;7(6):703–710. doi: 10.1016/0361-9230(81)90122-2. [DOI] [PubMed] [Google Scholar]
  3. Banda M. J., Knighton D. R., Hunt T. K., Werb Z. Isolation of a nonmitogenic angiogenesis factor from wound fluid. Proc Natl Acad Sci U S A. 1982 Dec;79(24):7773–7777. doi: 10.1073/pnas.79.24.7773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Beebe B. K., Møllgård K., Björklund A., Stenevi U. Ultrastructural evidence of synaptogenesis in the adult rat dentate gyrus from brain stem implants. Brain Res. 1979 May 11;167(2):391–395. doi: 10.1016/0006-8993(79)90833-3. [DOI] [PubMed] [Google Scholar]
  5. Björklund A., Dunnett S. B., Stenevi U., Lewis M. E., Iversen S. D. Reinnervation of the denervated striatum by substantia nigra transplants: functional consequences as revealed by pharmacological and sensorimotor testing. Brain Res. 1980 Oct 20;199(2):307–333. doi: 10.1016/0006-8993(80)90692-7. [DOI] [PubMed] [Google Scholar]
  6. Björklund A., Segal M., Stenevi U. Functional reinnervation of rat hippocampus by locus coeruleus implants. Brain Res. 1979 Jul 20;170(3):409–426. doi: 10.1016/0006-8993(79)90961-2. [DOI] [PubMed] [Google Scholar]
  7. Björklund A., Stenevi U. Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res. 1979 Nov 30;177(3):555–560. doi: 10.1016/0006-8993(79)90472-4. [DOI] [PubMed] [Google Scholar]
  8. Björklund A., Stenevi U. Reformation of the severed septohippocampal cholinergic pathway in the adult rat by transplanted septal neurons. Cell Tissue Res. 1977 Dec 19;185(3):289–302. doi: 10.1007/BF00220290. [DOI] [PubMed] [Google Scholar]
  9. Burry R. W. Antimitotic drugs that enhance neuronal survival in olfactory bulb cell cultures. Brain Res. 1983 Feb 21;261(2):261–275. doi: 10.1016/0006-8993(83)90629-7. [DOI] [PubMed] [Google Scholar]
  10. Das G. D., Hallas B. H., Das K. G. Transplantation of brain tissue in the brain of rat. I. Growth characteristics of neocortical transplants from embryos of different ages. Am J Anat. 1980 Jun;158(2):135–145. doi: 10.1002/aja.1001580204. [DOI] [PubMed] [Google Scholar]
  11. Dunnett S. B., Low W. C., Iversen S. D., Stenevi U., Björklund A. Septal transplants restore maze learning in rats with fornix-fimbria lesions. Brain Res. 1982 Nov 18;251(2):335–348. doi: 10.1016/0006-8993(82)90751-x. [DOI] [PubMed] [Google Scholar]
  12. Gash D., Sladek J. R., Jr, Sladek C. D. Functional development of grafted vasopressin neurons. Science. 1980 Dec 19;210(4476):1367–1369. doi: 10.1126/science.7434031. [DOI] [PubMed] [Google Scholar]
  13. Harvey A. R., Golden G. T., Lund R. D. Transplantation of tectal tissue in rats. III. Functional innervation of transplants by host afferents. Exp Brain Res. 1982;47(3):437–445. doi: 10.1007/BF00239361. [DOI] [PubMed] [Google Scholar]
  14. Krieger D. T., Perlow M. J., Gibson M. J., Davies T. F., Zimmerman E. A., Ferin M., Charlton H. M. Brain grafts reverse hypogonadism of gonadotropin releasing hormone deficiency. Nature. 1982 Jul 29;298(5873):468–471. doi: 10.1038/298468a0. [DOI] [PubMed] [Google Scholar]
  15. Kromer L. F., Björklund A., Stenevi U. Regeneration of the septohippocampal pathways in adult rats is promoted by utilizing embryonic hippocampal implants as bridges. Brain Res. 1981 Apr 6;210(1-2):173–200. doi: 10.1016/0006-8993(81)90893-3. [DOI] [PubMed] [Google Scholar]
  16. Labbe R., Firl A., Jr, Mufson E. J., Stein D. G. Fetal brain transplant: reduction of cognitive deficits in rats with frontal cortex lesions. Science. 1983 Jul 29;221(4609):470–472. doi: 10.1126/science.6683427. [DOI] [PubMed] [Google Scholar]
  17. Lewis E. R., Cotman C. W. Mechanisms of septal lamination in the developing hippocampus analyzed by outgrowth of fibers from septal implants. II. Absence of guidance by degenerative debris. J Neurosci. 1982 Jan;2(1):66–77. doi: 10.1523/JNEUROSCI.02-01-00066.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Lewis E. R., Cotman C. W. Mechanisms of septal lamination in the developing hippocampus revealed by outgrowth of fibers from septal implants. I. Positional and temporal factors. Brain Res. 1980 Sep 8;196(2):307–330. doi: 10.1016/0006-8993(80)90398-4. [DOI] [PubMed] [Google Scholar]
  19. Lewis E. R., Cotman C. W. Mechanisms of septal lamination in the developing hippocampus revealed by outgrowth of fibers from septal implants. III. Competitive interactions. Brain Res. 1982 Feb 4;233(1):29–44. doi: 10.1016/0006-8993(82)90927-1. [DOI] [PubMed] [Google Scholar]
  20. Lewis E. R., Cotman C. W. Neurotransmitter characteristics of brain grafts: striatal and septal tissues form the same laminated input to the hippocampus. Neuroscience. 1983 Jan;8(1):57–66. doi: 10.1016/0306-4522(83)90025-8. [DOI] [PubMed] [Google Scholar]
  21. Lewis E. R., Mueller J. C., Cotman C. W. Neonatal septal implants: development of afferent lamination in the rat dentate gyrus. Brain Res Bull. 1980 May-Jun;5(3):217–221. doi: 10.1016/0361-9230(80)90160-4. [DOI] [PubMed] [Google Scholar]
  22. Manthorpe M., Nieto-Sampedro M., Skaper S. D., Lewis E. R., Barbin G., Longo F. M., Cotman C. W., Varon S. Neuronotrophic activity in brain wounds of the developing rat. Correlation with implant survival in the wound cavity. Brain Res. 1983 May 9;267(1):47–56. doi: 10.1016/0006-8993(83)91038-7. [DOI] [PubMed] [Google Scholar]
  23. Nieto-Sampedro M., Lewis E. R., Cotman C. W., Manthorpe M., Skaper S. D., Barbin G., Longo F. M., Varon S. Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site. Science. 1982 Aug 27;217(4562):860–861. doi: 10.1126/science.7100931. [DOI] [PubMed] [Google Scholar]
  24. Nieto-Sampedro M., Manthrope M., Barbin G., Varon S., Cotman C. W. Injury-induced neuronotrophic activity in adult rat brain: correlation with survival of delayed implants in the wound cavity. J Neurosci. 1983 Nov;3(11):2219–2229. doi: 10.1523/JNEUROSCI.03-11-02219.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Skaper S. D., Adler R., Varon S. A procedure for purifying neuron-like cells in cultures from central nervous tissue with a defined medium. Dev Neurosci. 1979;2(5):233–237. doi: 10.1159/000112485. [DOI] [PubMed] [Google Scholar]
  26. Stenevi U., Björklund A., Svendgaard N. A. Transplantation of central and peripheral monoamine neurons to the adult rat brain: techniques and conditions for survival. Brain Res. 1976 Sep 10;114(1):1–20. doi: 10.1016/0006-8993(76)91003-9. [DOI] [PubMed] [Google Scholar]
  27. Trimmer P. A., Reier P. J., Oh T. H., Eng L. F. An ultrastructural and immunocytochemical study of astrocytic differentiation in vitro: changes in the composition and distribution of the cellular cytoskeleton. J Neuroimmunol. 1982 Jun;2(3-4):235–260. doi: 10.1016/0165-5728(82)90058-3. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES