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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Gastroenterology. 2013 Sep 22;146(1):257–267. doi: 10.1053/j.gastro.2013.09.044

Figure 4.

Figure 4

Wnt signaling occurs specifically in the MCN stroma. (A) Nuclear translocation of β-catenin is specifically observed in the stromal cells, but not the cyst epithelium in the KDD mouse model. β-catenin staining of PanIN lesions (B) and PDAC (C) induced in compound LSL-KrasG12D;Ptf1a-cre; elastase-tva mice injected with RCAS-Wnt1. Cytoplasmic β-catenin staining can be observed in some epithelial cells in PDAC. (D) Staining for Axin2 in PDAC cells (arrows), but not stroma. β-catenin staining in PanIN lesions (E) and PDAC (F) identified in the KDD mouse model.