Table 1.

Association analysis of four SNPs in the LRP8 gene with CAD and MI.

	Allele		MAF		OR	P
	Risk	Minor	Cases	Controls		HW	Observed	Adjusted	Empirical
GeneQuest CAD (N = 381) and control (N = 560)
rs7546246	C	C	0.461	0.399	1.29	0.38	0.011	0.002	0.012
rs2297660	A	A	0.446	0.386	1.28	0.47	0.014	0.007	0.017
rs3737983	T	T	0.474	0.402	1.34	0.14	0.003	0.001	0.003
rs5177	G	G	0.436	0.389	1.22	0.19	0.047	0.012	0.049
GeneQuest MI (N = 183) and control (N = 560)
rs7546246	C	C	0.470	0.399	1.33	0.38	0.018	0.003	0.019
rs2297660	A	A	0.467	0.386	1.40	0.47	0.006	0.008	0.007
rs3737983	T	T	0.486	0.402	1.41	0.14	0.005	0.003	0.005
rs5177	G	G	0.449	0.389	1.28	0.19	0.029	0.012	0.033
Italian MI (N = 248) and control (N = 308)
rs7546246	C	C	0.424	0.338	1.44	0.36	0.004	0.007	0.005
rs2297660	A	A	0.439	0.331	1.58	0.53	3.0 × 10−4	8.0 × 10−4	3.0 × 10−4
rs3737983	T	T	0.416	0.350	1.32	0.64	0.027	0.009	0.030
rs5177	G	G	0.421	0.347	1.37	0.29	0.012	0.008	0.015
Combined (CAD/MI = 629; control = 868)
rs7546246	C	C	0.445	0.378	1.32	0.46	3.0 × 10−4	8.0 × 10−4	7.0 × 10−4
rs2297660	A	A	0.446	0.367	1.39	0.21	2.0 × 10−5	1.0 × 10−4	2.0 × 10−4
rs3737983	T	T	0.449	0.384	1.31	0.15	4.0 × 10−4	1.0 × 10−4	5.0 × 10−4
rs5177	G	G	0.432	0.374	1.27	0.15	0.002	0.003	0.002

MAF: minor allele frequency; OR: odds ratio; P-HW: P-value for Hardy–Weinberg disequilibrium analysis; P-observed: uncorrected P-value; P-adjusted: P-value obtained after adjustment for gender, age, hypertension, diabetes and plasma total cholesterol levels; P-empirical: permutation P-value calculated using 10,000 Monte Carlo simulations.