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. Author manuscript; available in PMC: 2014 Feb 10.
Published in final edited form as: Gene. 2013 Mar 21;521(1):78–81. doi: 10.1016/j.gene.2013.03.022

Table 3.

Association analysis of a protective haplotype TCCGC of LRP8 with CAD and MI in GeneQuest and the Italian population.

Populations Haplotype Frequency
OR P
Cases Controls Observed Empirical
GeneQuest CAD and control TCCGC 0.439 0.595 0.53 4.0 × 10−11 <1 × 10−7
GeneQuest MI and control TCCGC 0.388 0.595 0.42 6.5 × 10−12 <1 × 10−7
Italian MI and control TCCGC 0.576 0.646 0.71 0.004 0.008
Combined TCCGC 0.490 0.613 0.61 3.0 × 10−11 <1 × 10−7

P-observed: uncorrected P-value; P-empirical: permutation P-value calculated using 1000 to 10,000,000 simulations.