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. 1984 Nov;81(21):6714–6717. doi: 10.1073/pnas.81.21.6714

A dual role for the Ca2+-requiring proteinase in the degradation of hemoglobin by erythrocyte membrane proteinases.

S Pontremoli, E Melloni, B Sparatore, M Michetti, B L Horecker
PMCID: PMC392001  PMID: 6093116

Abstract

Binding of hemoglobin chains to erythrocyte membranes is an obligatory step in the conversion of hemoglobin to acid-soluble products by erythrocyte proteinases. This binding requires limited proteolysis of the hemoglobin chains and also modification of the inner surface of the erythrocyte membrane, both of which result from the action of a soluble Ca2+-requiring neutral proteinase. Final digestion of the bound hemoglobin chains in the membrane complex results from the action of intrinsic membrane endopeptidases. Regulation of the activity of the Ca2+-requiring proteinase by the substrate provides a mechanism for the initiation of selective protein turnover.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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