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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1984 Nov;81(21):6733–6737. doi: 10.1073/pnas.81.21.6733

Transcriptional induction of two genes in human cells by beta interferon.

A C Larner, G Jonak, Y S Cheng, B Korant, E Knight, J E Darnell Jr
PMCID: PMC392005  PMID: 6436820

Abstract

The binding of interferons to distinct cell surface receptors leads to the induction of synthesis of several unique polypeptides and their corresponding mRNAs (1-6). We have isolated two cDNAs that are complementary to nuclear RNA whose synthesis is induced from undetectable levels to maximal rates of transcription within 30-60 min after the addition of beta interferon to human fibroblasts or to HeLa cells. These results prove that a single polypeptide can, by binding to a specific plasma membrane receptor, promptly activate the transcription of a defined set of genes.

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Selected References

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