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. 1984 Nov;81(22):7212–7215. doi: 10.1073/pnas.81.22.7212

Slow virus visna: reproduction in vitro of virus from extrachromosomal DNA.

J D Harris, H Blum, J Scott, B Traynor, P Ventura, A Haase
PMCID: PMC392108  PMID: 6095275

Abstract

Under permissive conditions of growth in tissue culture, the retrovirus visna multiples over the course of a few days to high titer and kills the host cell. We show that in this lytic life cycle, viral DNA is tightly associated with, but not covalently linked to, chromosomal DNA. This finding provides explanations for a number of the unusual properties of the lentivirus subfamily of retroviruses, and suggests potential mechanisms for the block in virus gene expression in vivo responsible for the slow infection in nature.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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