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. 1984 Nov;81(22):7221–7223. doi: 10.1073/pnas.81.22.7221

Denervation of rat adrenal glands markedly increases preproenkephalin mRNA.

D L Kilpatrick, R D Howells, G Fleminger, S Udenfriend
PMCID: PMC392110  PMID: 6594691

Abstract

The effect of denervation on the expression of rat adrenal proenkephalin has been examined. Following splanchnicectomy there was a several-fold increase in the steady-state levels of preproenkephalin mRNA, which became maximal after 24-48 hr (greater than 10-fold). These results indicate that the previously observed increase in rat adrenal enkephalin-containing peptides following denervation occurs entirely by a pretranslational mechanism. The increase in preproenkephalin mRNA was accompanied by a 50-75% decrease in rat adrenal poly(A)+ RNA. Neural input thus exerts a profound trophic influence on proenkephalin gene expression and RNA metabolism in rat adrenals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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