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. 2014 Mar;20(3):360–372. doi: 10.1261/rna.041657.113

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© 2014 Ninova et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article, published in RNA, is available under a Creative Commons License (Attribution 3.0 Unported), as described at http://creativecommons.org/licenses/by/3.0/.

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FIGURE 4. — Evolution and expression of the mir-310∼313 cluster members. (A) Schematic diagram of the evolutionary history of the extended mir-92/mir-310 family. Individual chromosomes or scaffolds and presented with a black line and oriented in the direction of the corresponding microRNA transcript(s). MicroRNAs annotated in miRBase are labeled, while homologs found by BLAST/INFERNAL searches are blank. Homologs of flanking protein-coding genes are shown as colored blocks. (B) Expression levels of the members of the mir-310∼313 cluster in small RNA libraries from different developmental stages of D. melanogaster and D. virilis. Horizontal axis labels are as in Figures 2 and 3. (C) Alignments of mir-310 family members in D. melanogaster and D. virilis. Mature arms are marked in uppercase and conserved sites between 1-to-1 orthologs are highlighted. (D) Total number of reads across experiments mapping to the 5′ and the 3′ arms of mir-310∼313 cluster members in D. melanogaster and D. virilis.