Abstract
Fischer rat embryo cells infected with xenotropic mouse type-C RNA viruses isolated from either NIH Swiss mice or C57L inbred mice were transformed by 4-nitroquinoline oxide or 3-methylcholanthrene under conditions in which neither treatment alone sufficed to induce transformation. Transformation was dependent on the presence of actively growing virus at the time of chemical treatment. Specific antibody to xenotropic virus neutralized the virus and inhibited malignant transformation by 3-methylcholanthrene.
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Selected References
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- Arnstein P., Riggs J. L., Oshiro L. S., Huebner R. J., Lennette E. H. Induction of lymphoma and associated xenotropic type C virus in C57L mice by whole-body irradiation. J Natl Cancer Inst. 1976 Nov;57(5):1085–1090. doi: 10.1093/jnci/57.5.1085. [DOI] [PubMed] [Google Scholar]
- Freeman A. E., Igel H. J., Price P. J. I. In vitrol transformation of rat embryo cells: correlations with the known tumorigenic activities of chemicals in rodents. In Vitro. 1975 Mar-Apr;11(2):107–116. doi: 10.1007/BF02624083. [DOI] [PubMed] [Google Scholar]
- Freeman A. E., Price P. J., Igel H. J., Young J. C., Maryak J. M., Huebner R. J. Morphological transformation of rat embryo cells induced by diethylnitrosamine and murine leukemia viruses. J Natl Cancer Inst. 1970 Jan;44(1):65–78. [PubMed] [Google Scholar]
- Huebner R. J., Gilden R. V., Toni R., Hill R. W., Trimmer R. W., Fish D. C., Sass B. Prevention of spontaneous leukemia in AKR mice by type-specific immunosuppression of endogenous ecotropic virogenes. Proc Natl Acad Sci U S A. 1976 Dec;73(12):4633–4635. doi: 10.1073/pnas.73.12.4633. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ioachim H. L., Berwick L. Continuous viral replication and cellular neoplastic transformation in cultures of normal rat thymus infected with gross leukemia virus. Int J Cancer. 1968 Jan 15;3(1):61–73. doi: 10.1002/ijc.2910030109. [DOI] [PubMed] [Google Scholar]
- Kelloff G. J., Hatanaka M., Gilden R. V. Assay of C-type virus infectivity by measurement of RNA-dependent DNA polymerase activity. Virology. 1972 Apr;48(1):266–269. doi: 10.1016/0042-6822(72)90135-3. [DOI] [PubMed] [Google Scholar]
- Kelloff G. J., Peters R. L., Donahoe R. M., Stephenson J. R., Aaronson S. A. Natural occurrence of tumors in mouse strains with different xenotropic and ecotropic endogenous viruses. J Natl Cancer Inst. 1976 Jul;57(1):85–89. doi: 10.1093/jnci/57.1.85. [DOI] [PubMed] [Google Scholar]
- MOLONEY J. B. Biological studies on a lymphoid-leukemia virus extracted from sarcoma 37. I. Origin and introductory investigations. J Natl Cancer Inst. 1960 Apr;24:933–951. [PubMed] [Google Scholar]
- McAllister R. M., Melnyk J., Finkelstein J. Z., Adams E. C., Jr, Gardner M. B. Cultivation in vitro of cells derived from a human rhabdomyosarcoma. Cancer. 1969 Sep;24(3):520–526. doi: 10.1002/1097-0142(196909)24:3<520::aid-cncr2820240313>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
- Price P. J., Bellew T. M., King M. P., Freeman A. E., Gilden R. V., Huebner R. J. Prevention of viral-chemical co-carcinogenesis in vitro by type-specific anti-viral antibody. Proc Natl Acad Sci U S A. 1976 Jan;73(1):152–155. doi: 10.1073/pnas.73.1.152. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Price P. J., Suk W. A., Freeman A. E. Type C RNA tumor viruses as determinants of chemical carcinogenesis: effects of sequence of treatment. Science. 1972 Sep 15;177(4053):1003–1004. doi: 10.1126/science.177.4053.1003. [DOI] [PubMed] [Google Scholar]
- Todaro G. J., Arnstein P., Parks W. P., Lennette E. H., Huebner R. J. A type-C virus in human rhabdomyosarcoma cells after inoculation into NIH Swiss mice treated with antithymocyte serum. Proc Natl Acad Sci U S A. 1973 Mar;70(3):859–862. doi: 10.1073/pnas.70.3.859. [DOI] [PMC free article] [PubMed] [Google Scholar]