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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1977 Feb;74(2):698–701. doi: 10.1073/pnas.74.2.698

Polymorphism and the subunit structure of enzymes: a contribution to the neutralist-selectionist controversy.

H Harris, D A Hopkinson, Y H Edwards
PMCID: PMC392360  PMID: 265532

Abstract

The occurrence of polymorphism in a series of 87 different loci coding for enzyme structure in human populations has been related to the size and the number of subunits in the corresponding enzymes. Polymorphic and nonpolymorphic enzymes did not differ on average in subunit size. However, multimeric enzymes showed a significantly lower incidence of polymorphism than didmonomeric enzymes. A particularly low incidence of polymorphism was noted among multimeric enzymes in which interlocus molecular hybrids occur. The findings are discussed in terms of the "neutralist" and "selectionist" hypotheses of polymorphism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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