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. 1978 Apr;75(4):1637–1641. doi: 10.1073/pnas.75.4.1637

Unique structures formed by pyrimidine-purine DNAs which may be four-stranded.

D Johnson, A R Morgan
PMCID: PMC392393  PMID: 273896

Abstract

Pyrimidine-purine DNAs with repeating sequences can be made to undergo a reversible transition to possibly a tetra-stranded complex. Physicochemical characterization of the new structures and model building are consistent with, in the case of d(TC)n-d(GA)n, a tetra-stranded complex forming by the addition of d(GA)n to the remaining space in the major groove of the triple-stranded complex d(TC)n-d(GA)n-d(CT)n. A possible role for tetra-stranded complexes in chromosome condensation is suggested by the natural occurrence of repeating sequence pyrimidine-purine DNAs and the properties of condensed chromosomes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arnott S., Chandrasekaran R., Marttila C. M. Structures for polyinosinic acid and polyguanylic acid. Biochem J. 1974 Aug;141(2):537–543. doi: 10.1042/bj1410537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Arnott S., Selsing E. Structures for the polynucleotide complexes poly(dA) with poly (dT) and poly(dT) with poly(dA) with poly (dT). J Mol Biol. 1974 Sep 15;88(2):509–521. doi: 10.1016/0022-2836(74)90498-7. [DOI] [PubMed] [Google Scholar]
  3. Benyajati C., Worcel A. Isolation, characterization, and structure of the folded interphase genome of Drosophila melanogaster. Cell. 1976 Nov;9(3):393–407. doi: 10.1016/0092-8674(76)90084-2. [DOI] [PubMed] [Google Scholar]
  4. Birnboim H. C., Straus N. A. DNA from eukaryotic cells contains unusually long pyrimidine sequences. Can J Biochem. 1975 May;53(5):640–643. doi: 10.1139/o75-088. [DOI] [PubMed] [Google Scholar]
  5. Coulter M., Flintoff W., Paetkau V., Pulleyblank D., Morgan A. R. In vitro synthesis and detection of deoxyribonucleic acids with covalently linked complementary sequences. Biochemistry. 1974 Apr 9;13(8):1603–1609. doi: 10.1021/bi00705a008. [DOI] [PubMed] [Google Scholar]
  6. Kubitschek H. E., Henderson T. R. DNA rplication. Proc Natl Acad Sci U S A. 1966 Mar;55(3):512–519. doi: 10.1073/pnas.55.3.512. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. McGavin S. Models of specifically paired like (homologous) nucleic acid structures. J Mol Biol. 1971 Jan 28;55(2):293–298. doi: 10.1016/0022-2836(71)90201-4. [DOI] [PubMed] [Google Scholar]
  8. Morgan A. R., Coulter M. B., Flintoff W. F., Paetkau V. H. Enzymatic synthesis of deoxyribonucleic acids with repeating sequences. A new repeating trinucleotide deoxyribonucleic acid, d(T-C-C)n-d(G-G-A)n. Biochemistry. 1974 Apr 9;13(8):1596–1603. doi: 10.1021/bi00705a007. [DOI] [PubMed] [Google Scholar]
  9. Morgan A. R. Model for DNA replication by Kornberg's DNA polymerase. Nature. 1970 Sep 26;227(5265):1310–1313. doi: 10.1038/2271310a0. [DOI] [PubMed] [Google Scholar]
  10. Morgan A. R., Pulleyblank D. E. Native and denatured DNA, cross-linked and palindromic DNA and circular covalently-closed DNA analysed by a sensitive fluorometric procedure. Biochem Biophys Res Commun. 1974 Nov 27;61(2):396–403. doi: 10.1016/0006-291x(74)90970-x. [DOI] [PubMed] [Google Scholar]
  11. Morgan A. R. Studies on polynucleotides. XCIV. Transcription of DNA's with repeating nucleotide sequences. J Mol Biol. 1970 Sep 28;52(3):441–466. doi: 10.1016/0022-2836(70)90412-2. [DOI] [PubMed] [Google Scholar]
  12. Morgan A. R., Wells R. D. Specificity of the three-stranded complex formation between double-stranded DNA and single-stranded RNA containing repeating nucleotide sequences. J Mol Biol. 1968 Oct 14;37(1):63–80. doi: 10.1016/0022-2836(68)90073-9. [DOI] [PubMed] [Google Scholar]
  13. Szala S., Michalska J., Paterak H., Bieniek B., Chorazy M. Inverted sequences in rat DNA. FEBS Lett. 1977 May 1;77(1):94–98. doi: 10.1016/0014-5793(77)80200-7. [DOI] [PubMed] [Google Scholar]
  14. Zimmerman S. B., Cohen G. H., Davies D. R. X-ray fiber diffraction and model-building study of polyguanylic acid and polyinosinic acid. J Mol Biol. 1975 Feb 25;92(2):181–192. doi: 10.1016/0022-2836(75)90222-3. [DOI] [PubMed] [Google Scholar]

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