Table 2.
Adjusted* Odds Ratio (and 95% confidence interval) from logistic† and GEE‡ regression models for quartiles of oxLDL-IC in relation to elevated internal carotid IMT and IMT progression.
| 6 Year ICA IMT† | 12 Year ICA IMT† | IMT Progression Year 1 to 12† | Elevated ICA IMT‡ | |
|---|---|---|---|---|
| Model 1* | ||||
| Lowest Quartile | 1.00 | 1.00 | 1.00 | 1.00 |
| Quartile 2 | 1.65 (0.74-3.66) | 1.35 (0.57-3.19) | 1.66 (0.70-3.95) | 1.94 (0.91-4.14) |
| Quartile 3 | 1.53 (0.67-3.49) | 2.09 (0.84-5.24) | 1.89 (0.75-4.78) | 2.13 (0.99-4.57) |
| Quartile 4 | 2.72 (1.24-5.97) | 3.99 (1.69-9.40) | 4.93 (2.08-11.7) | 4.78 (2.30-9.91) |
| ROC AUC | 0.748 | 0.813 | 0.797 | --- |
| Model 2* | ||||
| Lowest Quartile | 1.00 | 1.00 | 1.00 | 1.00 |
| Quartile 2 | 1.18 (0.52-2.67) | 1.10 (0.44-2.74) | 1.55 (0.59-4.03) | 1.32 (0.61-2.89) |
| Quartile 3 | 1.13 (0.49-2.61) | 1.89 (0.74-4.87) | 1.94 (0.74-5.07) | 1.66 (0.78-3.55) |
| Quartile 4 | 1.79 (0.78-4.12) | 3.52 (1.36-9.10) | 5.13 (1.98-13.3) | 2.98 (1.34-6.62) |
| ROC AUC | 0.778 | 0.849 | 0.833 | --- |
| Model 3* | ||||
| Lowest Quartile | 1.00 | 1.00 | 1.00 | 1.00 |
| Quartile 2 | 1.69 (0.71-4.02) | 1.05 (0.38-2.90) | 1.47 (0.51-4.25) | 1.31 (0.56-3.05) |
| Quartile 3 | 1.52 (0.62-3.75) | 1.71 (0.60-4.85) | 2.06 (0.72-5.88) | 1.73 (0.74-4.03) |
| Quartile 4 | 3.04 (1.24-7.49) | 4.18 (1.48-11.8) | 5.89 (2.12-16.4) | 3.66 (1.52-8.79) |
| ROC AUC | 0.785 | 0.862 | 0.845 | --- |
*
Model 1 is adjusted for age, gender, primary retinopathy cohort, diabetes duration, natural log of AER, IMT reader ID and closeout HbA1c; Model 2 is additionally adjusted for LDL-C, HDL-C, SBP at DCCT closeout; smoking status at enrollment; ACE/ARB use and statin use through EDIC year 12 and study mean HbA1c rather than closeout HbA1c; Model 3 is adjusted for LDL and HDL mean particle concentration rather than LDL and HDL cholesterol levels.